Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration
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BACKGROUND: The skeletal muscle stem cell niche provides an environment that maintains quiescent satellite cells, required for skeletal muscle homeostasis and regeneration. Syndecan-3, a transmembrane proteoglycan expressed in satellite cells, supports communication with the niche, providing cell interactions and signals to maintain quiescent satellite cells. RESULTS: Syndecan-3 ablation unexpectedly improves regeneration in repeatedly injured muscle and in dystrophic mice, accompanied by the persistence of sublaminar and interstitial, proliferating myoblasts. Additionally, muscle aging is improved in syndecan-3 null mice. Since syndecan-3 null myofiber-associated satellite cells downregulate Pax7 and migrate away from the niche more readily than wild type cells, syxndecan-3 appears to regulate satellite cell homeostasis and satellite cell homing to the niche. CONCLUSIONS: Manipulating syndecan-3 provides a promising target for development of therapies to enhance muscle regeneration in muscular dystrophies and in aged muscle.
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Diminishment of the SC pool is not observed when SCs-SC niche molecular interactions are interrupted in muscles lacking Wnt4, N-, and M-cadherins or syndecan-3.
“Interestingly, diminishment of the SC pool is not observed when SCs-SC niche molecular interactions are interrupted in muscles lacking Wnt4, N-, and M-cadherins or syndecan-323,39,40.”
From In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche (2021) · cites this paper as [40]
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Defining Skeletal Muscle Progenitors
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- Authors
- Pisconti, A., Banks, G. B., Babaeijandaghi, F., Betta, N. D., Rossi, F. M. V., Chamberlain, J. S., & Olwin, B. B.
- Affiliations
- University of Liverpool (GB)
- University of Washington (US)
- University of British Columbia (CA)
- University of Colorado Boulder (US)
- Corresponding author
- Pisconti, Addolorata
- Olwin, Bradley B.
- ORCID
- Venue
- Skeletal Muscle
- Published
- 2016-10-04
- Volume
- 6
- Issue
- 1
- Pages
- 34-34
- ISSN
- 2044-5040 (ISSN-L)
- PMC
- PMC5064903
- OpenAlex
- W2530090145
- Cited by
- 50
- References
- 73
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 8 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 6
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Skeletal Muscle (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CU Scholar (University of Colorado Boulder) (submittedVersion)
- cIRcle (University of British Columbia) (submittedVersion, cc-by)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01049446)
- National Institute on Aging (R01AG040074)
- Welcome Trust (ISSF)
- Canadian Institutes of Health Research (MOP-97856)
- Marie Curie IEF
- University of British Columbia (4YF)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- syndecan-3, satellite cells, muscle regeneration, Pax7, muscle aging, muscular dystrophy, myoblast proliferation, proteoglycans
- MeSH terms
- Animals, Female, Homeostasis, Male, Regeneration, Mice, Knockout, Muscle, Skeletal, Satellite Cells, Skeletal Muscle, Mice, Syndecan-3, Stem Cell Niche
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