The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Wnt/β-catenin signaling is sufficient and necessary for synovial joint formation
Open accessAbstract
A critical step in skeletal morphogenesis is the formation of synovial joints, which define the relative size of discrete skeletal elements and are required for the mobility of vertebrates. We have found that several Wnt genes, including Wnt4, Wnt14, and Wnt16, were expressed in overlapping and complementary patterns in the developing synovial joints, where β-catenin protein levels and transcription activity were up-regulated. Removal of β-catenin early in mesenchymal progenitor cells promoted chondrocyte differentiation and blocked the activity of Wnt14 in joint formation. Ectopic expression of an activated form of β-catenin or Wnt14 in early differentiating chondrocytes induced ectopic joint formation both morphologically and molecularly. In contrast, genetic removal of β-catenin in chondrocytes led to joint fusion. These results demonstrate that the Wnt/β-catenin signaling pathway is necessary and sufficient to induce early steps of synovial joint formation. Wnt4, Wnt14, and Wnt16 may play redundant roles in synovial joint induction by signaling through the β-catenin-mediated canonical Wnt pathway.
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Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721
Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling
Suzuki, T., Takeuchi, J., Koshiba-Takeuchi, K., & Ogura, T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00401-5 · Cited by 148
Cited by
WNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093
Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.03.016 · Cited by 1,616
Self-citationCanonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation.
Glass, D. A., Bialek, P., Ahn, J. D., Starbuck, M., Patel, M. S., Clevers, H., Taketo, M. M., Long, F., McMahon, A. P., Lang, R. A., et al. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.017 · Cited by 1,558
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
Hill, T. P., Später, D., Taketo, M. M., Birchmeier, W., & Hartmann, C. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.02.013 · Cited by 1,084
Metadata
- Authors
- Guo, X., Day, T. F., Jiang, X., Garrett-Beal, L., Topol, L., & Yang, Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-09-15
- Volume
- 18
- Issue
- 19
- Pages
- 2404-2417
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2166428507
- Cited by
- 391
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Guo, X., Day, T. F., Jiang, X., Garrett-Beal, L., Topol, L., & Yang, Y. (2004). Wnt/β-catenin signaling is sufficient and necessary for synovial joint formation. Genes & Development. https://doi.org/10.1101/gad.1230704
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