Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis
Open accessAbstract
Chondrocytes and osteoblasts are two primary cell types in the skeletal system that are differentiated from common mesenchymal progenitors. It is believed that osteoblast differentiation is controlled by distinct mechanisms in intramembranous and endochondral ossification. We have found that ectopic canonical Wnt signaling leads to enhanced ossification and suppression of chondrocyte formation. Conversely, genetic inactivation of beta-catenin, an essential component transducing the canonical Wnt signaling, causes ectopic formation of chondrocytes at the expense of osteoblast differentiation during both intramembranous and endochondral ossification. Moreover, inactivation of beta-catenin in mesenchymal progenitor cells in vitro causes chondrocyte differentiation under conditions allowing only osteoblasts to form. Our results demonstrate that beta-catenin is essential in determining whether mesenchymal progenitors will become osteoblasts or chondrocytes regardless of regional locations or ossification mechanisms. Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification.
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β-catenin is required for bone formation and is activated during multiple stages of osteoblast differentiation to regulate both osteoblast and osteoclast.
“Many studies have demonstrated that β-catenin is required for bone formation and is activated during multiple stages of osteoblast differentiation to regulate both osteoblast and osteoclast.40–43”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [40]
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- Authors
- Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Yang, Yingzi
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 8
- Issue
- 5
- Pages
- 739-750
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W1981284961
- Cited by
- 1,616
- References
- 62
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- FWCI
- 27.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- Wnt/β-catenin signaling, mesenchymal progenitor cells, osteogenic differentiation, chondrogenic differentiation, skeletal development, intramembranous ossification, endochondral ossification, cell fate specification
- MeSH terms
- Animals, Bone Development, Cell Differentiation, Cytoskeletal Proteins, Lac Operon, Mesoderm, Mice, Transgenic, Models, Biological, Osteoblasts, Osteogenesis, Stem Cells, Signal Transduction, Trans-Activators, In Situ Hybridization, Gene Expression Regulation, Developmental, Chondrocytes, Chondrogenesis, Intercellular Signaling Peptides and Proteins, Cell Size, Wnt Proteins, beta Catenin, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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