Cited by 1,616Wnt/β-catenin signaling in development and cancerBone Metabolism and DiseasesOsteoarthritis Treatment and Mechanisms

Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis

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Day, Timothy F., Guo, Xizhi, Garrett-Beal, Lisa, Yang, Yingzi·2005·Developmental Cell

Abstract

Chondrocytes and osteoblasts are two primary cell types in the skeletal system that are differentiated from common mesenchymal progenitors. It is believed that osteoblast differentiation is controlled by distinct mechanisms in intramembranous and endochondral ossification. We have found that ectopic canonical Wnt signaling leads to enhanced ossification and suppression of chondrocyte formation. Conversely, genetic inactivation of beta-catenin, an essential component transducing the canonical Wnt signaling, causes ectopic formation of chondrocytes at the expense of osteoblast differentiation during both intramembranous and endochondral ossification. Moreover, inactivation of beta-catenin in mesenchymal progenitor cells in vitro causes chondrocyte differentiation under conditions allowing only osteoblasts to form. Our results demonstrate that beta-catenin is essential in determining whether mesenchymal progenitors will become osteoblasts or chondrocytes regardless of regional locations or ossification mechanisms. Controlling Wnt/beta-catenin signaling is a common molecular mechanism underlying chondrocyte and osteoblast differentiation and specification of intramembranous and endochondral ossification.

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Crossref · 10.1016/j.devcel.2005.03.016

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  • β-catenin is required for bone formation and is activated during multiple stages of osteoblast differentiation to regulate both osteoblast and osteoclast.

    “Many studies have demonstrated that β-catenin is required for bone formation and is activated during multiple stages of osteoblast differentiation to regulate both osteoblast and osteoclast.40–43”

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  1. drogenic cell lineage in the cranial neural crest. Proc. Natl. Acad.

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Authors
Day, T. F., Guo, X., Garrett-Beal, L., & Yang, Y.
Affiliations
National Institutes of Health (US)
Corresponding author
Yang, Yingzi
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2005-05
Volume
8
Issue
5
Pages
739-750
ISSN
1534-5807 (ISSN-L)
OpenAlex
W1981284961
Cited by
1,616
References
62
Citations by year
2026: 33 · 2025: 41 · 2024: 51 · 2023: 29 · 2022: 70 · 2021: 94 · 2020: 86 · 2019: 84 · 2018: 101 · 2017: 83 · 2016: 85 · 2015: 84 · 2014: 99 · 2013: 118 · 2012: 105
FWCI
27.11
Type
journal article
Language
en
Open access
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords
Wnt/β-catenin signaling, mesenchymal progenitor cells, osteogenic differentiation, chondrogenic differentiation, skeletal development, intramembranous ossification, endochondral ossification, cell fate specification
MeSH terms
Animals, Bone Development, Cell Differentiation, Cytoskeletal Proteins, Lac Operon, Mesoderm, Mice, Transgenic, Models, Biological, Osteoblasts, Osteogenesis, Stem Cells, Signal Transduction, Trans-Activators, In Situ Hybridization, Gene Expression Regulation, Developmental, Chondrocytes, Chondrogenesis, Intercellular Signaling Peptides and Proteins, Cell Size, Wnt Proteins, beta Catenin, Mice, In Vitro Techniques

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