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Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana
Open accessAbstract
The plant hormone auxin regulates diverse aspects of plant growth and development. We report that in Arabidopsis, auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1. The complex consists of proteins related to yeast Skp1p and Cdc53p called ASK and AtCUL1, respectively, as well as the F-box protein TIR1. Mutations in either ASK1 or TIR1 result in decreased auxin response. Further, overexpression of TIR1 promotes auxin response suggesting that SCFTIR1 is limiting for the response. These results provide new support for a model in which auxin action depends on the regulated proteolysis of repressor proteins.
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Cited by
The F-box protein TIR1 is an auxin receptor
Dharmasiri, N., Dharmasiri, S., & Estelle, M. (2005) · Nature · doi:10.1038/nature03543 · Cited by 2,083
Self-citationAn auxin-based degron system for the rapid depletion of proteins in nonplant cells
Nishimura, K., Fukagawa, T., Takisawa, H., Kakimoto, T., & Kanemaki, M. (2009) · Nature Methods · doi:10.1038/nmeth.1401 · Cited by 1,663
Okushima, Y., Overvoorde, P. J., Arima, K., Alonso, J. M., Chan, A., Chang, C., Ecker, J. R., Hughes, B., Lui, A., Nguyen, D., et al. (2005) · The Plant Cell · doi:10.1105/tpc.104.028316 · Cited by 1,122
Plant Development Is Regulated by a Family of Auxin Receptor F Box Proteins
Dharmasiri, N., Dharmasiri, S., Weijers, D., Lechner, E., Yamada, M., Hobbie, L., Ehrismann, J. S., Jürgens, G., & Estelle, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.014 · Cited by 997
Self-citationDissecting Arabidopsis lateral root development
Casimiro, I., Beeckman, T., Graham, N., Bhalerao, R., Zhang, H., Casero, P., Sandberg, G., & Bennett, M. J. (2003) · Trends in Plant Science · doi:10.1016/s1360-1385(03)00051-7 · Cited by 683
Metadata
- Authors
- Gray, W. M., del Pozo, J. C., Walker, L., Hobbie, L., Risseeuw, E., Banks, T., Crosby, W. L., Yang, M., Ma, H., & Estelle, M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-07-01
- Volume
- 13
- Issue
- 13
- Pages
- 1678-1691
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2103539812
- Cited by
- 525
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Gray, W. M., del Pozo, J. C., Walker, L., Hobbie, L., Risseeuw, E., Banks, T., Crosby, W. L., Yang, M., Ma, H., & Estelle, M. (1999). Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana. Genes & Development. https://doi.org/10.1101/gad.13.13.1678
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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