The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Axis determination by inhibition of Wnt signaling in Xenopus
Open accessAbstract
The Wnt family of secreted polypeptides participate in a variety of developmental processes in which embryonic polarity is established. To study a role for Wnt ligands in vertebrate axis determination, we interfered with Wnt signaling in the embryo using the extracellular domain of Xenopus Frizzled 8 (ECD8), which blocks Wnt-dependent activation of a target gene in Xenopus ectodermal explants. Expression of ECD8 in ventral blastomeres resulted in formation of secondary axes containing abundant notochord and head structures. These results suggest that Wnt signaling is required to maintain ventral cell fates and has to be suppressed for dorsal development to occur.
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Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759 · cited 5×
“as Cerberus (Bouwmeester et al. 1996), Dkk-1 (Glinka et al.”
BackgroundInfluentialFrzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518 · cited 11×
“Nevertheless, the dominant-negative form of Xwnt8 and some FRPs inhibited myoD expression in the marginal zone (Hoppler et al. 1996; Leyns et al. 1997; Salic et al. 1997; Wang et al. 1997a), implicating Xwnt8 or related Wnt products in muscle development.”
BackgroundInfluential
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Metadata
- Authors
- Itoh, K., & Sokol, S. Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-09-01
- Volume
- 13
- Issue
- 17
- Pages
- 2328-2336
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2093147450
- Cited by
- 163
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Itoh, K., & Sokol, S. Y. (1999). Axis determination by inhibition of Wnt signaling in Xenopus. Genes & Development. https://doi.org/10.1101/gad.13.17.2328
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