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The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast
Open accessAbstract
Chromosome segregation depends on kinetochores, the structures that mediate chromosome attachment to the mitotic spindle. We isolated mutants in IPL1, which encodes a protein kinase, in a screen for budding yeast mutants that have defects in sister chromatid separation and segregation. Cytological tests show that ipl1 mutants can separate sister chromatids but are defective in chromosome segregation. Kinetochores assembled in extracts from ipl1 mutants show altered binding to microtubules. Ipl1p phosphorylates the kinetochore component Ndc10p in vitro and we propose that Ipl1p regulates kinetochore function via Ndc10p phosphorylation. Ipl1p localizes to the mitotic spindle and its levels are regulated during the cell cycle. This pattern of localization and regulation is similar to that of Ipl1p homologs in higher eukaryotes, such as the human aurora2 protein. Because aurora2 has been implicated in oncogenesis, defects in kinetochore function may contribute to genetic instability in human tumors.
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Citations
Cited by
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Cheung, P., Allis, C. D., & Sassone-Corsi, P. (2000) · Cell · doi:10.1016/s0092-8674(00)00118-5 · Cited by 989
Harrington, E. A., Bebbington, D., Moore, J., Rasmussen, R. K., Ajose-Adeogun, A. O., Nakayama, T., Graham, J. A., Demur, C., Hercend, T., Diu-Hercend, A., et al. (2004) · Nature Medicine · doi:10.1038/nm1003 · Cited by 965
Tanaka, T. U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M. J. R., & Nasmyth, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00633-5 · Cited by 722
Sensing centromere tension: Aurora B and the regulation of kinetochore function
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Metadata
- Authors
- Biggins, S., Severin, F. F., Bhalla, N., Sassoon, I., Hyman, A. A., & Murray, A. W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-03-01
- Volume
- 13
- Issue
- 5
- Pages
- 532-544
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2132547886
- Cited by
- 400
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Biggins, S., Severin, F. F., Bhalla, N., Sassoon, I., Hyman, A. A., & Murray, A. W. (1999). The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes & Development. https://doi.org/10.1101/gad.13.5.532
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