Sensing centromere tension: Aurora B and the regulation of kinetochore function

Lampson, Michael A.; Cheeseman, Iain M.

doi:10.1016/j.tcb.2010.10.007

Cited by 375Microtubule and mitosis dynamicsGenomics and Chromatin DynamicsDNA Repair Mechanisms

Sensing centromere tension: Aurora B and the regulation of kinetochore function

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Lampson, Michael A., Cheeseman, Iain M.·2011·Trends in Cell Biology

DOI 10.1016/j.tcb.2010.10.007PMC PMC3049846

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Abstract

Maintaining genome integrity during cell division requires regulated interactions between chromosomes and spindle microtubules. To ensure that daughter cells inherit the correct chromosomes, the sister kinetochores must attach to opposite spindle poles. Tension across the centromere stabilizes correct attachments, whereas phosphorylation of kinetochore substrates by the conserved Ipl1/Aurora B kinase selectively eliminates incorrect attachments. Here, we review our current understanding of how mechanical forces acting on the kinetochore are linked to biochemical changes to control chromosome segregation. We discuss models for tension sensing and regulation of kinetochore function downstream of Aurora B, and mechanisms that specify Aurora B localization to the inner centromere and determine its interactions with substrates at distinct locations.

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A balanced phosphorylation/dephosphorylation system is critical to maintain the fine spatial gradients of Aurora B phosphorylation at the kinetochore, where tension is thought to allow substrate movement into and out of the regions of highest Aurora B kinase activity.
“This type of balanced phosphorylation/dephosphorylation system is going to be critical to maintain the fine spatial gradients of Aurora B phosphorylation at the kinetochore, wherein tension is thought to allow substrate movement into and out of the regions of highest Aurora B kinase activity [59].”
From Regulatory mechanisms that control mitotic kinesins (2015) · cites this paper as [59]
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The molecular biology of spindle assembly checkpoint signaling dynamics.
Musacchio, A. (2015) · Current Biology · doi:10.1016/j.cub.2015.08.051 · Cited by 778 · see citing works
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“This type of balanced phosphorylation/dephosphorylation system is going to be critical to maintain the fine spatial gradients of Aurora B phosphorylation at the kinetochore, wherein tension is thought to allow substrate movement into and out of the regions of highest Aurora B kinase activity [59].”
Background

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling
Krenn, V., & Musacchio, A. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00225 · Cited by 273 · see citing works
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Mitosis: Aurora Gives Chromosomes a Healthy Stretch
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis
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Unrestrained Spindle Elongation during Recovery from Spindle Checkpoint Activation incdc15-2Cells Results in Mis-Segregation of Chromosomes
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Authors: Lampson, M. A., & Cheeseman, I. M.
Affiliations: University of Pennsylvania (US)
Whitehead Institute for Biomedical Research (US)
Corresponding author: Lampson, Michael A.
Cheeseman, Iain M.
ORCID: Lampson, Michael A.
Cheeseman, Iain M.
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2011-03
Volume: 21
Issue: 3
Pages: 133-140
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2010.10.007
PMC: PMC3049846
OpenAlex: W2138958608
Cited by: 375
References: 114
Citations by year: 2026: 12 · 2025: 15 · 2024: 9 · 2023: 8 · 2022: 15 · 2021: 21 · 2020: 25 · 2019: 26 · 2018: 20 · 2017: 27 · 2016: 27 · 2015: 31 · 2014: 33 · 2013: 37 · 2012: 42
FWCI: 3.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
PMC
Funders: Searle Scholars Program
National Institutes of Health
National Institute of General Medical Sciences (GM088313, R01GM088313, R01GM083988, GM083988)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: Aurora B kinase, kinetochore function, chromosome segregation, kinetochore-microtubule attachment, tension sensing, inner centromere, genome stability
MeSH terms: Animals, Humans, Models, Biological, Substrate Specificity, Protein Serine-Threonine Kinases, Kinetochores, Biophysical Phenomena, Aurora Kinase B, Aurora Kinases

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Sensing centromere tension: Aurora B and the regulation of kinetochore function

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