The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh
Open accessAbstract
The inner ear is partitioned along its dorsal/ventral axis into vestibular and auditory organs, respectively. Gene expression studies suggest that this subdivision occurs within the otic vesicle, the tissue from which all inner ear structures are derived. While the specification of ventral otic fates is dependent on Shh secreted from the notochord, the nature of the signal responsible for dorsal otic development has not been described. In this study, we demonstrate that Wnt signaling is active in dorsal regions of the otic vesicle, where it functions to regulate the expression of genes ( Dlx5/6 and Gbx2 ) necessary for vestibular morphogenesis. We further show that the source of Wnt impacting on dorsal otic development emanates from the dorsal hindbrain, and identify Wnt1 and Wnt3a as the specific ligands required for this function. The restriction of Wnt target genes to the dorsal otocyst is also influenced by Shh. Thus, a balance between Wnt and Shh signaling activities is key in distinguishing between vestibular and auditory cell types.
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Cites
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Cited by
Grigoryan, T., Wend, P., Klaus, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 560
3D mouse embryonic stem cell culture for generating inner ear organoids
Koehler, K. R., & Hashino, E. (2014) · Nature Protocols · doi:10.1038/nprot.2014.100 · Cited by 157
Reconstruction of the Mouse Otocyst and Early Neuroblast Lineage at Single-Cell Resolution
Durruthy-Durruthy, R., Gottlieb, A., Hartman, B. H., Waldhaus, J., Laske, R. D., Altman, R., & Heller, S. (2014) · Cell · doi:10.1016/j.cell.2014.03.036 · Cited by 148
Visualizing WNT signaling in mammalian systems
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Metadata
- Authors
- Riccomagno, M. M., Takada, S., & Epstein, D. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2005-06-16
- Volume
- 19
- Issue
- 13
- Pages
- 1612-1623
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2153044032
- Cited by
- 263
- References
- 53
- Type
- posted content
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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