The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Translational control of C/EBPα and C/EBPβ isoform expression
Open accessAbstract
Transcription factors derived from CCAAT/enhancer binding protein (C/EBP)α and C/EBPβ genes control differentiation and proliferation in a number of cell types. Various C/EBP isoforms arise from unique C/EBPβ and C/EBPα mRNAs by differential initiation of translation. These isoforms retain different parts of the amino terminus and therefore display different functions in gene regulation and proliferation control. We show that PKR and mTOR signaling pathways control the ratio of C/EBP isoform expression through the eukaryotic translation initiation factors eIF-2α and eIF-4E, respectively. An evolutionary conserved upstream open reading frame in C/EBPα and C/EBPβ mRNAs is a prerequisite for regulated initiation from the different translation initiation sites and integrates translation factor activity. Deregulated translational control leading to aberrant C/EBPα and C/EBPβ isoform expression or ectopic expression of truncated isoforms disrupts terminal differentiation and induces a transformed phenotype in 3T3-L1 cells. Our results demonstrate that the translational controlled ratio of C/EBPα and C/EBPβ isoform expression determines cell fate.
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Cites
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
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Impaired Energy Homeostasis in C/EBPα Knockout Mice
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CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch
Umek, R. M., Friedman, A. D., & McKnight, S. L. (1991) · Science · doi:10.1126/science.1987644 · Cited by 712
Birkenmeier, E. H., Gwynn, B., Howard, S., Jerry, J., Gordon, J. I., Landschulz, W. H., & McKnight, S. L. (1989) · Genes & Development · doi:10.1101/gad.3.8.1146 · Cited by 613
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Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice
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C/EBP, c-Myb, and PU.1 Cooperate To Regulate the Neutrophil Elastase Promoter
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Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
Nerlov, C., McNagny, K. M., Döderlein, G., Kowenz-Leutz, E., & Graf, T. (1998) · Genes & Development · doi:10.1101/gad.12.15.2413 · Cited by 119
Cited by
Lu, P. D., Harding, H. P., & Ron, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408003 · Cited by 1,006
Upstream Open Reading Frames as Regulators of mRNA Translation
Morris, D. R., & Geballe, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8635-8642.2000 · Cited by 736
Transcription factors in myeloid development: balancing differentiation with transformation
Rosenbauer, F., & Tenen, D. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2024 · Cited by 606
Rutkowski, D. T., Wu, J., Back, S.-H., Callaghan, M. U., Ferris, S. P., Iqbal, J., Clark, R., Miao, H., Hassler, J. R., Fornek, J., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.10.015 · Cited by 580
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I. L., Mittermaier, M., Mache, C., Chua, R. L., Knoll, R., Timm, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.033 · Cited by 528
Metadata
- Authors
- Calkhoven, C. F., Müller, C., & Leutz, A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-08-01
- Volume
- 14
- Issue
- 15
- Pages
- 1920-1932
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W4296404860
- Cited by
- 426
- References
- 12
- Type
- posted content
- Language
- en
- Open access
- diamond
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