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Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis

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Li, Ling, Vaessin, Harald·2000·Genes & Development

Abstract

Organogenesis requires coordination between developmental specific regulators and genes governing cell proliferation. Here we show that Drosophila prospero encodes a critical regulator of the transition from mitotically active cells to terminal differentiated neurons. Loss of pros results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity. In contrast, ectopic pros expression causes transcriptional suppression of multiple cell-cycle regulatory genes and premature termination of cell division. pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes.

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Metadata

Authors
Li, L., & Vaessin, H.
Venue
Genes & Development
Published
2000-01-15
Volume
14
Issue
2
Pages
147-151
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
OpenAlex
W1923305081
Cited by
208
References
0
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. https://app.cochat.ai/papers/10.1101/gad.14.2.147
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Li, L., & Vaessin, H. (2000). Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes & Development. https://doi.org/10.1101/gad.14.2.147

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