Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning
Open accessAbstract
Differentiation of the embryonic termini in Drosophila depends on signaling by the Tor RTK, which induces terminal gene expression by inactivating at the embryonic poles a uniformly distributed repressor activity that involves the Gro corepressor. Here, we identify a new gene, cic, that acts as a repressor of terminal genes regulated by the Tor pathway. cic also mediates repression along the dorsoventral axis, a process that requires the Dorsal morphogen and Gro, and which is also inhibited by Tor signaling at the termini. cic encodes an HMG-box transcription factor that interacts with Gro in vitro. We present evidence that Tor signaling regulates terminal patterning by inactivating Cic at the embryo poles. cic has been evolutionarily conserved, suggesting that Cic-like proteins may act as repressors regulated by RTK signaling in other organisms.
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Torso signaling modulates the ability of Capicua, Cut, and Dri to function, proteins that influence the ability of Dorsal to function as a transcriptional repressor.
“Torso signaling modulates the ability of Capicua (Cic), Cut, and Dri to function, proteins that influence the ability of Dorsal to function as a transcriptional repressor”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Jimenez et al. 2000
Cites
Conversion of Dorsal from an activator to a repressor by the global corepressor Groucho
Dubnicoff, T., Valentine, S. A., Chen, G., Shi, T., Lengyel, J. A., Paroush, Z., & Courey, A. J. (1997) · Genes & Development · doi:10.1101/gad.11.22.2952 · Cited by 155 · see citing works
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Graded dorsal and differential gene regulation in the Drosophila embryo.
Reeves, G. T., & Stathopoulos, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000836 · Cited by 119 · see citing works
Substrate-dependent control of MAPK phosphorylation in vivo
Kim, Y., Paroush, Z., Nairz, K., Hafen, E., Jiménez, G., & Shvartsman, S. Y. (2011) · Molecular Systems Biology · doi:10.1038/msb.2010.121 · Cited by 80 · see citing works
Self-citationPapatsenko, D., & Levine, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409414102 · Cited by 82 · see citing works
- Authors
- Jiménez, G., Guichet, A., Ephrussi, A., & Casanova, J.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-01-15
- Volume
- 14
- Issue
- 2
- Pages
- 224-231
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC316342
- OpenAlex
- W2096720319
- Cited by
- 232
- References
- 1
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 19 · 2019: 12 · 2018: 17 · 2017: 21 · 2016: 9 · 2015: 9 · 2014: 8 · 2013: 10 · 2012: 12
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Generalitat de Catalunya
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- TOR signaling, Capicua, dorsoventral patterning, HMG-box transcription factor, receptor tyrosine kinase signaling, gene repression, Drosophila embryo, transcriptional repression
- MeSH terms
- Amino Acid Sequence, Animals, Drosophila melanogaster, Female, High Mobility Group Proteins, Humans, Molecular Sequence Data, Mutation, Protein Processing, Post-Translational, Repressor Proteins, Suppression, Genetic, Transcription Factors, Signal Transduction, Conserved Sequence, Evolution, Molecular, Body Patterning, Receptor Protein-Tyrosine Kinases, HMGB Proteins, Drosophila Proteins
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