The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
Open accessAbstract
Msh4 (MutS homolog 4) is a member of the mammalian mismatch repair gene family whose members are involved in postreplicative DNA mismatch repair as well as in the control of meiotic recombination. In this report we show that MSH4 has an essential role in the control of male and female meiosis. We demonstrate that MSH4 is present in the nuclei of spermatocytes early in prophase I and that it forms discrete foci along meiotic chromosomes during the zygotene and pachytene stages of meiosis. Disruption of the Msh4 gene in mice results in male and female sterility due to meiotic failure. Although meiosis is initiated in Msh4 mutant male and female mice, as indicated by the chromosomal localization of RAD51 and COR1 during leptonema/zygonema, the chromosomes fail to undergo normal pairing. Our results show that MSH4 localization on chromosomes during the early stages of meiosis is essential for normal chromosome synapsis in prophase I and that it acts in the same pathway as MSH5.
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Cites
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
Marsischky, G. T., Filosi, N., Kane, M. F., & Kolodner, R. (1996) · Genes & Development · doi:10.1101/gad.10.4.407 · Cited by 581
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Cited by
Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing
Chen, M., Yao, C., Qin, Y., Cui, X., Li, P., Ji, Z., Lin, L., Wu, H., Zhou, Z., Gui, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00710-4 · Cited by 528
Yokoo, R., Zawadzki, K. A., Nabeshima, K., Drake, M., Arur, S., & Villeneuve, A. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.052 · Cited by 256
Metadata
- Authors
- Kneitz, B., Cohen, P. E., Avdievich, E., Zhu, L., Kane, M. F., Hou, H., Kolodner, R. D., Kucherlapati, R., Pollard, J. W., & Edelmann, W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-05-01
- Volume
- 14
- Issue
- 9
- Pages
- 1085-1097
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2101650794
- Cited by
- 476
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kneitz, B., Cohen, P. E., Avdievich, E., Zhu, L., Kane, M. F., Hou, H., Kolodner, R. D., Kucherlapati, R., Pollard, J. W., & Edelmann, W. (2000). MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes & Development. https://doi.org/10.1101/gad.14.9.1085
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