PreprintCited by 897Epigenetics and DNA MethylationChromatin Remodeling and CancerGenomics and Chromatin Dynamics

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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Tan, Jing, Yang, Xiaojing, Zhuang, Li, Jiang, Xia, Chen, Wei, Lee, Puay Leng, Karuturi, R.K. Murthy, Tan, Patrick Boon Ooi, Liu, Edison T., Yu, Qiang·2007·Genes & Development

DOI 10.1101/gad.1524107PMC PMC1855231

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Abstract

Polycomb-repressive complex 2 (PRC2)-mediated histone methylation plays an important role in aberrant cancer gene silencing and is a potential target for cancer therapy. Here we show that S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A (DZNep) induces efficient apoptotic cell death in cancer cells but not in normal cells. We found that DZNep effectively depleted cellular levels of PRC2 components EZH2, SUZ12, and EED and inhibited associated histone H3 Lys 27 methylation (but not H3 Lys 9 methylation). By integrating RNA interference (RNAi), genome-wide expression analysis, and chromatin immunoprecipitation (ChIP) studies, we have identified a prominent set of genes selectively repressed by PRC2 in breast cancer that can be reactivated by DZNep. We further demonstrate that the preferential reactivation of a set of these genes by DZNep, including a novel apoptosis affector, FBXO32 , contributes to DZNep-induced apoptosis in breast cancer cells. Our results demonstrate the unique feature of DZNep as a novel chromatin remodeling compound and suggest that pharmacologic reversal of PRC2-mediated gene repression by DZNep may constitute a novel approach for cancer therapy.

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1 retracted

Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1
Beisel, C., Imhof, A., Greene, J., Kremmer, E., & Sauer, F. (2002) · Nature · doi:10.1038/nature01126 · Cited by 310
Retracted
The fundamental role of epigenetic events in cancer
Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845 · cited 1×
“In contrast, histone H3 trimethylation at Lys 9 (H3-K9me3)—which is mediated by another histone MTase, Suv39h1 (Rea et al. 2000; Peters et al. 2001; Lehnertz et al. 2003)—was not affected by DZNep treatment.”
Background
The polycomb group protein EZH2 is involved in progression of prostate cancer
Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568
The history of cancer epigenetics
Feinberg, A. P., & Tycko, B. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1279 · Cited by 2,404
Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G., Levine, S. S., Kumar, R., Chevalier, B. S., Johnstone, S. E., Cole, M. F., Isono, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.043 · Cited by 2,296
The Polycomb group protein EZH2 directly controls DNA methylation
Viré, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.-M., et al. (2006) · Nature · doi:10.1038/nature04431 · Cited by 2,204

Show all 68 references

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Ma, X., Jiang, S., Huang, Y., Zou, Y., Zheng, R., & Xiao, L. (2011) · InTech eBooks · doi:10.5772/21265
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Takebe, N., Harris, P. J., Kondo, Y., Nair, A., Ivy, S. P., & Saya, H. (2014) · Wiley eBooks · doi:10.1002/9781118356203.ch23
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Bhalla, K. N. (2007) · doi:10.21236/ada484223
Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs
Wang, X. (2014) · Figshare
Correction: EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers
Au, S. L., Wong, C. C., Lee, J. M., Ng, I. O., & Ng, I. O. (2014) · PLoS ONE · doi:10.1371/annotation/9085e9bd-25b1-4266-b6db-34e56d80ce3a
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Kleb, B. (2014) · Digital Commons-TMC (Texas Medical Center)
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Carvalho, D. D. D. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2009.tde-03022010-091640
Genetic and Epigenetic Characterisation of Breast Tumours
Holm, K. (2011) · Lund University Publications (Lund University)
Functional analysis of the core subunits of Polycomb Repressive Complex 2
Nair, A. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)
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Alumkal, J. J., & Herman, J. G. (2012)
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Jacobs, D. (2014)
Rapid Advances in the Field of Epigenetics
Kawamura, T. (2014) · Translational bioinformatics · doi:10.1007/978-94-017-9202-8_10
Epigenetic gene regulation of differentiation and epithelial-mesenchymal transition in mammary epithelial cells
Fu, X. R. N. (2012) · Common Library Network (Der Gemeinsame Bibliotheksverbund)
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Arranz, L., Herrera-Merchan, A., & González, S. (2012) · Recent Patents on Regenerative Medicine · doi:10.2174/2210296511202010022
Dosing – When Less is More
Pandiyan, K., Jones, P. A., & Baylin, S. B. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781782628484-00249
Targeting Histone Lysine Methyltransferases in Cancer
Trojer, P. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781782628484-00127
Epigenetic Regulation of EZH2 and Its Targeted MicroRNAs
Au, S. L., Ng, I. O., & Wong, C. (2013) · Springer eBooks · doi:10.1007/978-94-007-6612-9_3
Enhancer of Zeste Homology 2 (Ezh2), an Epigenetic Regulator: A Possibility for Prostate Cancer Treatment
Kumar, S., Stokes, J. A., III, Singh, U. P., Bishnupuri, K. S., & Mishra, M. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-24951-3_10
Epigenomics
Kaur, J., & Kaur, J. (2013) · CRC Press eBooks · doi:10.1201/b14289-5
Theepigenetic profile of bladder cancer
Dudziec, E., & Catto, J. W. F. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777271.029
Molecular Targeted Therapy
Haas-Kogan, D. A., & McBride, S. M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5897-7.00073-1
High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancer
Tudy, P. S. (2012)
Epigenetic mechanisms in development, inheritance and disease
Bollen, M., Minnebo, N., & Eynde, A. V. (2012)
Theranostic Approaches for Pathway-Activated Systems in Oncology
Pham, L. V., Bryant, J. L., Yang, D. J., & Ford, R. J. (2017) · Springer eBooks · doi:10.1007/978-981-10-3349-0_2
Comparative Analysis of Heterochromatin in the Anopheles gambiae Complex
Sharma, A. (2016) · VTechWorks (Virginia Tech)
Fundamental Pathways in Breast Cancer 4: Signaling to Chromatin in Breast Development
Mazzarella, L., & Pelicci, P. G. (2017) · Springer eBooks · doi:10.1007/978-3-319-48848-6_4
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Vierra, D. A. (2017) · doi:10.23860/diss-vierra-david-2017
Investigation of approaches for overcoming chemoresistance in pancreatic cancer
Hung, S. W. (2014)
Targeting epigenetics and Nrf2-pathway by dietary phytochemicals
Yang, Y. (2017) · doi:10.7282/t3k64n8d
Targeting of Epigenetic Modifier EZH2 in Oropharyngeal Squamous Cell Carcinomas
Lindsay, C. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3cn6zf0h
Polycomb Proteins and their Roles in Skin Development and Regeneration
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Bátai, B., Lévai, D., Weisinger, J., Balogh, A., Gángó, A., Bödör, C., & Nagy, N. (2018) · Hematológia–Transzfuziológia · doi:10.1556/2068.2018.51.2.3
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Zhang, Q. (2015) · NDSU Repository (North Dakota State University)
The contribution of methyltransferases : demethylases to renal fibrosis
Nawafa, L. S. O. (2018)
The methyl cycle is a conserved regulator of biological clocksPreprint
Fustin, J., Ye, S., Rakers, C., Versteven, M., Cargill, S. J., Tamai, K. T., Xu, Y. Q., Jabbur, M. L., Kojima, R., Lamberti, M. L., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/653667
Identification of Novel Therapeutic Strategies Against MLL-rearranged Acute Lymphoblastic Leukemia in Infants
Kerstjens, M. J. (2019) · RePub (Erasmus University Rotterdam)
Emerging Epigenetic Targets and Their Implications in Cancer Therapy
Mansuri, M. S., & Mehrotra, S. (2019) · Springer eBooks · doi:10.1007/978-981-32-9816-3_7
Targeting histone modifications in cancer immunotherapy
Munera-Maravilla, E., Paramio, J. M., & Dueñas, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816422-8.00016-7
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Jiang, J., & Huang, C. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_11
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Felisbino, M. B. (2016) · doi:10.47749/t/unicamp.2016.976565
Epigenetics and its Applications to a Revised Progression Model of Pancreatic Cancer
Lomberk, G. A., & Urrutia, R. A. (2009) · Springer eBooks · doi:10.1007/978-0-387-77498-5_6
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Patil, S. (2020) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8223
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(2013) · Apple Academic Press eBooks · doi:10.1201/b16304-10
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Casciello, F. (2020) · Queensland University of Technology · doi:10.5204/thesis.eprints.200821
TP53-status dependent oncogenic EZH2 Activity in Pancreatic Cancer
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Sun, F., Chan, E., Wu, Z., Yang, X., Márquez, V. E., & Yu, Q. (2023) · doi:10.1158/1535-7163.c.6532019
Self-citation
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Sun, F., Chan, E., Wu, Z., Yang, X., Márquez, V. E., & Yu, Q. (2023) · doi:10.1158/1535-7163.c.6532019.v1
Self-citation
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Deb, G., Singh, A. K., & Gupta, S. (2023) · doi:10.1158/1541-7786.c.6539991.v1
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Sriraksa, R., Zeller, C., Dai, W., Siddiq, A., Walley, A. J., Limpaiboon, T., & Brown, R. E. (2023) · doi:10.1158/1940-6207.22525742.v1
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Ozgun, G., Yaraş, T., Landman, N., Karakülah, G., van Lohuizen, M., Şentürk, Ş., & Ozhan, S. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537500
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Song, X.-Q., Chen, B.-B., Jin, Y.-M., & Wang, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3240325/v1
Research Progress of Epigenetics in Liver Cancer
Fu, S., & Guo, M. (2024) · Journal of Cancer Therapy · doi:10.4236/jct.2024.153008
Additional file 7 of H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Zhu, S., Tao, M., Li, Y., Wang, X., Zhao, Z., Liu, Y., Li, Q., Li, Q., Lu, Y., Si, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730796
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Li, J., Wang, M., Yang, J., Cao, Z., Gu, Z., & Wang, Y. (2025) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-025-09058-x
Impact of epigenetic techniques and noncoding RNAs in neurological cancer
Choudhury, S., Kanavi, K. G., Arjun, K. R., Mythreyi, R., & Basalingappa, K. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-26635-5.00062-6
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Epigenetic gene regulation in multiple myeloma and mood disorders
Kalushkova, A. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
The Role of Polycomb Group Protein EZH2 in Cancer Progression.
Cao, Q. (2008)
[Prognosis and molecular pathogenesis of adult T-cell leukemia/lymphoma].
芳孝, 今. (2008) · PubMed
Additional file 5 of H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Zhu, S., Tao, M., Li, Y., Wang, X., Zhao, Z., Liu, Y., Li, Q., Li, Q., Lu, Y., Si, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730790
Additional file 1 of EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer
Chen, J., Hong, J. H., Huang, Y., Liu, S., Yin, J., Deng, P., Sun, Y., Yu, Z., Zeng, X., Xiao, R., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23001940
Self-citation
Additional file 1 of H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Zhu, S., Tao, M., Li, Y., Wang, X., Zhao, Z., Liu, Y., Li, Q., Li, Q., Lu, Y., Si, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730778
Additional file 4 of H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Zhu, S., Tao, M., Li, Y., Wang, X., Zhao, Z., Liu, Y., Li, Q., Li, Q., Lu, Y., Si, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730787
Additional file 2 of H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Zhu, S., Tao, M., Li, Y., Wang, X., Zhao, Z., Liu, Y., Li, Q., Li, Q., Lu, Y., Si, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730781
Additional file 1 of Chromatin remodeling by the histone methyltransferase EZH2 drives lung pre-malignancy and is a target for cancer prevention
Tellez, C. S., Picchi, M. A., Juri, D. E., Do, K., Desai, D. H., Amin, S. G., Hutt, J. A., Filipczak, P. T., & Belinsky, S. A. (2021) · Figshare · doi:10.6084/m9.figshare.14121404
Additional file 6 of H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Zhu, S., Tao, M., Li, Y., Wang, X., Zhao, Z., Liu, Y., Li, Q., Li, Q., Lu, Y., Si, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730793
Additional file 3 of H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection
Zhu, S., Tao, M., Li, Y., Wang, X., Zhao, Z., Liu, Y., Li, Q., Li, Q., Lu, Y., Si, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23730784
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Manu, J., Singh, U. S., Agboluaje, E. O., Whittaker, M. K., Kennedy, E. J., Chu, C. K., & Xiong, M. P. (2026) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2026.130600
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Ngollo, M. (2015) · doi:10.70675/768fbc61z4d3fz4645zac49z60bc498f7cc1
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Dupret, B. (2017) · theses.fr (ABES) · doi:10.70675/8f5fe7e1z5229z4a9eza0a5z877106bbd1be
Epigénétique et cancer de la prostate : Rôles de la déméthylase JMJD3 et de la méthyltransférase EZH2
Daures, M. (2018) · theses.fr (ABES) · doi:10.70675/ea4ac043z26daz46abzaacdzb99c3fe4d5d5
A trans-methylation mechanism between the two major H3K9 methyltransferases SETDB1 and SUV39H1 regulates heterochromatin establishment
Cruz‐Tapias, P. (2018) · theses.fr (ABES) · doi:10.70675/95b1db38zceccz4ac5z89f0z4d27b9f45efb
Nouvelles stratégies thérapeutiques dans le traitement du gliome infiltrant du tronc cérébral
Herrault, G. (2024) · theses.fr (ABES) · doi:10.70675/539ee639z4f77z47b3z903ez909ec614384d
DZNep : A Methyltransferase Modulator for Disease Mitigation
Garg, S., & Miousse, I. R. (2026) · Environmental and Molecular Mutagenesis · doi:10.1002/em.70071
Cancer epigenetic modulation mediated by phytochemicals
Goleij, P., Poudineh, M., Tabari, M. A. K., Alijanzadeh, D., Larsen, D. S., Daglia, M., Khan, H., & Kumar, A. P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34084-0.00009-1
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BindingDB Entry 50040549: Oncoepigenomics: making histone lysine methylation count.
BindingDB (2013) · UC San Diego · doi:10.7270/q2tq62nx

Authors: Tan, J., Yang, X., Zhuang, L., Jiang, X., Chen, W., Lee, P. L., Karuturi, R. K. M., Tan, P. B. O., Liu, E. T., & Yu, Q.
Affiliations: Genome Institute of Singapore (SG)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Duke-NUS Medical School (SG)
ORCID: Tan, Jing
Yang, Xiaojing
Zhuang, Li
Jiang, Xia
Chen, Wei
Lee, Puay Leng
Karuturi, R.K. Murthy
Liu, Edison T.
Yu, Qiang
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2007-04-16
Volume: 21
Issue: 9
Pages: 1050-1063
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1524107
PMC: PMC1855231
OpenAlex: W2113634596
Cited by: 895
References: 68
Citations by year: 2026: 12 · 2025: 16 · 2024: 18 · 2023: 35 · 2022: 21 · 2021: 35 · 2020: 39 · 2019: 37 · 2018: 44 · 2017: 65 · 2016: 55 · 2015: 65 · 2014: 98 · 2013: 77 · 2012: 70
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Funders: Agency for Science, Technology and Research
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: polycomb repressive complex 2, DZNep, EZH2, SUZ12, EED, histone H3 lysine 27 methylation, gene silencing, apoptosis, breast cancer, atrogin-1, chromatin remodeling, cancer therapy
MeSH terms: Adenosine, Base Sequence, Breast Neoplasms, Enzyme Inhibitors, Female, Histones, Humans, Methylation, Promoter Regions, Genetic, Repressor Proteins, RNA Polymerase II, Apoptosis, RNA Interference, RNA, Small Interfering, Chromatin Assembly and Disassembly, Adenosylhomocysteinase, Epigenesis, Genetic, Cell Line, Tumor, Chromatin Immunoprecipitation, Polycomb-Group Proteins

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

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