Cited by 5,648Epigenetics and DNA MethylationGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

The fundamental role of epigenetic events in cancer

Jones, Peter A., Baylin, Stephen B.·2002·Nature Reviews Genetics

Abstract

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia and include genome-wide losses of, and regional gains in, DNA methylation. The recent explosion in our knowledge of how chromatin organization modulates gene transcription has further highlighted the importance of epigenetic mechanisms in the initiation and progression of human cancer. These epigenetic changes -- in particular, aberrant promoter hypermethylation that is associated with inappropriate gene silencing -- affect virtually every step in tumour progression. In this review, we discuss these epigenetic events and the molecular alterations that might cause them and/or underlie altered gene expression in cancer.

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Crossref · 10.1038/nrg816

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Authors
Jones, P. A., & Baylin, S. B.
Affiliations
  • University of Southern California (US)
  • Johns Hopkins University (US)
Corresponding author
  • Jones, Peter A.
  • Baylin, Stephen B.
Venue
Nature Reviews Genetics
Published
2002-06
Volume
3
Issue
6
Pages
415-428
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
OpenAlex
W1504303645
Cited by
5,648
References
7
Citations by year
2026: 62 · 2025: 99 · 2024: 129 · 2023: 176 · 2022: 119 · 2021: 214 · 2020: 161 · 2019: 178 · 2018: 169 · 2017: 230 · 2016: 215 · 2015: 262 · 2014: 287 · 2013: 298 · 2012: 345
FWCI
16.92
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute
  • National Institute of Environmental Health Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
epigenetics, cancer, DNA methylation, chromatin structure, promoter hypermethylation, gene silencing, tumor progression, gene expression regulation, chromatin organization
MeSH terms
Chromosome Mapping, Humans, Mass Screening, Neoplasms, Signal Transduction, Genome, Human, DNA Methylation

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