The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Yin Yang 1 is a critical regulator of B-cell development
Open accessAbstract
The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a defect in somatic rearrangement in the immunoglobulin heavy-chain ( IgH ) locus and a block in the progenitor-B-to-precursor-B-cell transition, which was partially rescued by a prerearranged IgH transgene. Three-dimensional DNA fluorescence in situ hybridization analysis revealed an important function for YY1 in IgH locus contraction, a process indispensable for distal V H to D H J H recombination. We provide evidence that YY1 binds the intronic Eiμ enhancer within the IgH locus, consistent with a direct role for YY1 in V H D H J H recombination. These findings identified YY1 as a critical regulator of early B-cell development.
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Cites
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus
Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,235
Ordered rearrangement of immunoglobulin heavy chain variable region segments
Alt, F. W., Yancopoulos, G. D., Blackwell, T. K., Wood, C., Thomas, E., Boss, M., Coffman, R., Rosenberg, N., Tonegawa, S., & Baltimore, D. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01955.x · Cited by 733
Interchromosomal associations between alternatively expressed loci
Spilianakis, C. G., Lalioti, M. D., Town, T., Lee, G. R., & Flavell, R. A. (2005) · Nature · doi:10.1038/nature03574 · Cited by 730
Subnuclear Compartmentalization of Immunoglobulin Loci During Lymphocyte Development
Kosak, S. T., Skok, J. A., Medina, K. L., Riblet, R., Le Beau, M. M., Fisher, A. G., & Singh, H. (2002) · Science · doi:10.1126/science.1068768 · Cited by 722
Self-citationDevelopmentally controlled and tissue-specific expression of unrearranged VH gene segments
Yancopoulos, G. (1985) · Cell · doi:10.1016/0092-8674(85)90141-2 · Cited by 696
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
Su, I.-H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., & Tarakhovsky, A. (2003) · Nature Immunology · doi:10.1038/ni876 · Cited by 611
Caretti, G., Di Padova, M., Micales, B., Lyons, G. E., & Sartorelli, V. (2004) · Genes & Development · doi:10.1101/gad.1241904 · Cited by 600
Testing gene function early in the B cell lineage in mb1-cre mice
Hobeika, E., Thiemann, S., Storch, B., Jumaa, H., Nielsen, P. J., Pelanda, R., & Reth, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605944103 · Cited by 579
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Cited by
YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Weintraub, A. S., Li, C. H., Zamudio, A. V., Sigova, A. A., Hannett, N. M., Day, D. S., Abraham, B. J., Cohen, M. A., Nabet, B., Buckley, D. L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.008 · Cited by 992
Popay, T. M., & Dixon, J. R. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102117 · Cited by 94
LDB1 establishes multi-enhancer networks to regulate gene expression
Aboreden, N. G., Lam, J. C., Goel, V. Y., Wang, S., Wang, X., Midla, S. C., Quijano, A., Keller, C. A., Giardine, B. M., Hardison, R. C., et al. (2025) · Molecular Cell · doi:10.1016/j.molcel.2024.11.037 · Cited by 61
Metadata
- Authors
- Liu, H., Schmidt-Supprian, M., Shi, Y., Hobeika, E., Barteneva, N., Jumaa, H., Pelanda, R., Reth, M., Skok, J., Rajewsky, K., & Shi, Y.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-05-15
- Volume
- 21
- Issue
- 10
- Pages
- 1179-1189
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2107243811
- Cited by
- 264
- References
- 59
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Liu, H., Schmidt-Supprian, M., Shi, Y., Hobeika, E., Barteneva, N., Jumaa, H., Pelanda, R., Reth, M., Skok, J., Rajewsky, K., & Shi, Y. (2007). Yin Yang 1 is a critical regulator of B-cell development. Genes & Development. https://doi.org/10.1101/gad.1529307
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