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Testing gene function early in the B cell lineage in mb1-cre mice
Open accessAbstract
The mb1 gene encodes the Ig-α signaling subunit of the B cell antigen receptor and is expressed exclusively in B cells beginning at the very early pro-B cell stage in the bone marrow. We examine here the efficacy of the mb1 gene as a host locus for cre recombinase expression in B cells. We show that by integrating a humanized cre recombinase into the mb1 locus we obtain extraordinarily efficient recombination of loxP sites in the B cell lineage. The results from a variety of reporter genes including the splicing factor SRp20 and the DNA methylase Dnmt1 suggest that mb1-cre is probably the best model so far described for pan-B cell-specific cre expression. The availability of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function.
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Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499
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Ersching, J., Efeyan, A., Mesin, L., Jacobsen, J. T., Pasqual, G., Grabiner, B. C., Dominguez-Sola, D., Sabatini, D. M., & Victora, G. D. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.005 · Cited by 308
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., et al. (2018) · Nature · doi:10.1038/s41586-018-0701-2 · Cited by 285
Metadata
- Authors
- Hobeika, E., Thiemann, S., Storch, B., Jumaa, H., Nielsen, P. J., Pelanda, R., & Reth, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2006-09-12
- Volume
- 103
- Issue
- 37
- Pages
- 13789-13794
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1987318925
- Cited by
- 579
- References
- 2
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Hobeika, E., Thiemann, S., Storch, B., Jumaa, H., Nielsen, P. J., Pelanda, R., & Reth, M. (2006). Testing gene function early in the B cell lineage in mb1-cre mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0605944103
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