The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena
Open accessAbstract
Methylated H3K27 is an important mark for Polycomb group (PcG) protein-mediated transcriptional gene silencing (TGS) in multicellular eukaryotes. Here a Drosophila E(z) homolog, EZL1 , is characterized in the ciliated protozoan Tetrahymena thermophila and is shown to be responsible for H3K27 methylation associated with developmentally regulated heterochromatin formation and DNA elimination. Importantly, Ezl1p-catalyzed H3K27 methylation occurs in an RNA interference (RNAi)-dependent manner. H3K27 methylation also regulates H3K9 methylation in these processes. Furthermore, an “effector” of programmed DNA elimination, the chromodomain protein Pdd1p, is shown to bind both K27- and K9-methylated H3. These studies provide a framework for an RNAi-dependent, Polycomb group protein-mediated heterochromatin formation pathway in Tetrahymena and underscore the connection between the two highly conserved machineries in eukaryotes.
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Cites
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Lachner, M., O'Carroll, D., Rea, S., Mechtler, K., & Jenuwein, T. (2001) · Nature · doi:10.1038/35065132 · Cited by 2,868
Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi
Volpe, T. A., Kidner, C., Hall, I. M., Teng, G., Grewal, S. I. S., & Martienssen, R. A. (2002) · Science · doi:10.1126/science.1074973 · Cited by 2,055
Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
Nakayama, J.-I., Rice, J. C., Strahl, B. D., Allis, C. D., & Grewal, S. I. S. (2001) · Science · doi:10.1126/science.1060118 · Cited by 1,739
Self-citationKuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2002) · Genes & Development · doi:10.1101/gad.1035902 · Cited by 1,596
Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex
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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
Verdel, A., Jia, S., Gerber, S., Sugiyama, T., Gygi, S., Grewal, S. I. S., & Moazed, D. (2004) · Science · doi:10.1126/science.1093686 · Cited by 1,221
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Malone, C. D., & Hannon, G. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.045 · Cited by 836
Specialization and evolution of endogenous small RNA pathways
Chapman, E. J., & Carrington, J. C. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2179 · Cited by 696
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
Hogg, S. J., Motorna, O., Cluse, L. A., Johanson, T. M., Coughlan, H. D., Raviram, R., Myers, R. M., Costacurta, M., Todorovski, I., Pijpers, L., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.04.015 · Cited by 170
Small RNA-Mediated trans-Nuclear and trans-Element Communications in Tetrahymena DNA Elimination
Noto, T., & Mochizuki, K. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.071 · Cited by 22
Cai, X., Liu, Y., Li, J., Zhao, Z., Yao, X., Zhai, Z., Liucong, M., Liu, Y., Wang, X., Mochizuki, K., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3103-x · Cited by 1
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Metadata
- Authors
- Liu, Y., Taverna, S. D., Muratore, T. L., Shabanowitz, J., Hunt, D. F., & Allis, C. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-06-15
- Volume
- 21
- Issue
- 12
- Pages
- 1530-1545
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2166186329
- Cited by
- 257
- References
- 72
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Liu, Y., Taverna, S. D., Muratore, T. L., Shabanowitz, J., Hunt, D. F., & Allis, C. D. (2007). RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes & Development. https://doi.org/10.1101/gad.1544207
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