The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Rational design of memory in eukaryotic cells
Open accessAbstract
The ability to logically engineer novel cellular functions promises a deeper understanding of biological systems. Here we demonstrate the rational design of cellular memory in yeast that employs autoregulatory transcriptional positive feedback. We built a set of transcriptional activators and quantitatively characterized their effects on gene expression in living cells. Modeling in conjunction with the quantitative characterization of the activator-promoter pairs accurately predicts the behavior of the memory network. This study demonstrates the power of taking advantage of components with measured quantitative parameters to specify eukaryotic regulatory networks with desired properties.
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Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619
A positive-feedback-based bistable ‘memory module’ that governs a cell fate decision.
Xiong, W., & Ferrell, J. E. (2003) · Nature · doi:10.1038/nature02089 · Cited by 741
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Benenson, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3197 · Cited by 373
Next-generation synthetic gene networks
Lu, T. K., Khalil, A. S., & Collins, J. J. (2009) · Nature Biotechnology · doi:10.1038/nbt.1591 · Cited by 365
Programmable bacteria detect and record an environmental signal in the mammalian gut
Kotula, J. W., Kerns, S. J., Shaket, L. A., Siraj, L., Collins, J. J., Way, J. C., & Silver, P. A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321321111 · Cited by 361
Self-citationEmergent bistability by a growth-modulating positive feedback circuit
Tan, C., Marguet, P., & You, L. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.218 · Cited by 339
Metadata
- Authors
- Ajo-Franklin, C. M., Drubin, D. A., Eskin, J. A., Gee, E. P. S., Landgraf, D., Phillips, I., & Silver, P. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-09-15
- Volume
- 21
- Issue
- 18
- Pages
- 2271-2276
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2150207014
- Cited by
- 245
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Ajo-Franklin, C. M., Drubin, D. A., Eskin, J. A., Gee, E. P. S., Landgraf, D., Phillips, I., & Silver, P. A. (2007). Rational design of memory in eukaryotic cells. Genes & Development. https://doi.org/10.1101/gad.1586107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
