The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Programmable bacteria detect and record an environmental signal in the mammalian gut
Open accessAbstract
Significance: The human microbiota represents the trillions of bacteria that live on the skin, in the oral, nasal, and aural cavities, and throughout the gastrointestinal tract. The species that live in the gastrointestinal tract, the gut microbiota, closely interact with host cells and have a profound impact on health. To develop tools to effectively monitor the gut microbiota and ultimately help in disease diagnosis, we have engineered Escherichia coli to sense and record environmental stimuli, and demonstrated that E. coli with such memory systems can survive and function in the mammalian gut. This work demonstrates that E. coli can be engineered into living diagnostics capable of nondestructively probing the mammalian gut.
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Cites
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Self-citationHuman nutrition, the gut microbiome and the immune system
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Cited by
An insider's perspective: Bacteroides as a window into the microbiome
Wexler, A. G., & Goodman, A. L. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.26 · Cited by 641
An ingestible bacterial-electronic system to monitor gastrointestinal health
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Self-citationEngineering bacteria for diagnostic and therapeutic applications
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Self-citationEngineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation
Riglar, D. T., Giessen, T. W., Baym, M., Kerns, S. J., Niederhuber, M. J., Bronson, R. T., Kotula, J. W., Gerber, G. K., Way, J. C., & Silver, P. A. (2017) · Nature Biotechnology · doi:10.1038/nbt.3879 · Cited by 426
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Metadata
- Authors
- Kotula, J. W., Kerns, S. J., Shaket, L. A., Siraj, L., Collins, J. J., Way, J. C., & Silver, P. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-17
- Volume
- 111
- Issue
- 13
- Pages
- 4838-4843
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2162642438
- Cited by
- 361
- References
- 41
- FWCI
- 16.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Kotula, J. W., Kerns, S. J., Shaket, L. A., Siraj, L., Collins, J. J., Way, J. C., & Silver, P. A. (2014). Programmable bacteria detect and record an environmental signal in the mammalian gut. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1321321111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
