The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Dynamics and interplay of nuclear architecture, genome organization, and gene expression
Open accessAbstract
The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and dynamic. Various features of the nuclear architecture, including compartmentalization of molecular machines and the spatial arrangement of genomic sequences, help to carry out and regulate nuclear processes, such as DNA replication, DNA repair, gene transcription, RNA processing, and mRNA transport. Compartmentalized multiprotein complexes undergo extensive modifications or exchange of protein subunits, allowing for an exquisite dynamics of structural components and functional processes of the nucleus. The architecture of the interphase nucleus is linked to the spatial arrangement of genes and gene clusters, the structure of chromatin, and the accessibility of regulatory DNA elements. In this review, we discuss recent studies that have provided exciting insight into the interplay between nuclear architecture, genome organization, and gene expression.
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Cites
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Cited by
ATP-citrate lyase links cellular metabolism to histone acetylation
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CRISPR/Cas9 in Genome Editing and Beyond
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Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase
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Epigenetic Therapeutics: A New Weapon in the War Against Cancer
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Metadata
- Authors
- Schneider, R., & Grosschedl, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-12-01
- Volume
- 21
- Issue
- 23
- Pages
- 3027-3043
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1968384393
- Cited by
- 420
- References
- 11
- Type
- posted content
- Language
- en
- Open access
- diamond
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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