The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase
Open accessAbstract
Recent findings suggest important roles for nuclear organization in gene expression. In contrast, little is known about how nuclear organization contributes to genome stability. Epistasis analysis (E-MAP) using DNA repair factors in yeast indicated a functional relationship between a nuclear pore subcomplex and Slx5/Slx8, a small ubiquitin-like modifier (SUMO)–dependent ubiquitin ligase, which we show physically interact. Real-time imaging and chromatin immunoprecipitation confirmed stable recruitment of damaged DNA to nuclear pores. Relocation required the Nup84 complex and Mec1/Tel1 kinases. Spontaneous gene conversion can be enhanced in a Slx8- and Nup84-dependent manner by tethering donor sites at the nuclear periphery. This suggests that strand breaks are shunted to nuclear pores for a repair pathway controlled by a conserved SUMO-dependent E3 ligase.
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Self-citationToward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae
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Self-citationThe nuclear envelope and transcriptional control
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Dynamics and interplay of nuclear architecture, genome organization, and gene expression
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Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M.-C., Guan, A., Hesley, J. A., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.021 · Cited by 555
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Nuclear F-actin and myosins drive relocalization of heterochromatic breaks
Caridi, C. P., D’Agostino, C., Ryu, T., Zapotoczny, G., Delabaere, L., Li, X., Khodaverdian, V. Y., Amaral, N., Lin, E., Rau, A. R., et al. (2018) · Nature · doi:10.1038/s41586-018-0242-8 · Cited by 372
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Metadata
- Authors
- Nagai, S., Dubrana, K., Tsai-Pflugfelder, M., Davidson, M. B., Roberts, T. M., Brown, G. W., Varela, E., Hediger, F., Gasser, S. M., & Krogan, N. J.
- Venue
- Science
- Published
- 2008-10-24
- Volume
- 322
- Issue
- 5901
- Pages
- 597-602
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013158844
- Cited by
- 451
- References
- 30
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Nagai, S., Dubrana, K., Tsai-Pflugfelder, M., Davidson, M. B., Roberts, T. M., Brown, G. W., Varela, E., Hediger, F., Gasser, S. M., & Krogan, N. J. (2008). Functional Targeting of DNA Damage to a Nuclear Pore-Associated SUMO-Dependent Ubiquitin Ligase. Science. https://doi.org/10.1126/science.1162790
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