The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
The Ets transcription factor Elf5 specifies mammary alveolar cell fate
Open accessAbstract
Hormonal cues regulate mammary development, but the consequent transcriptional changes and cell fate decisions are largely undefined. We show that knockout of the prolactin-regulated Ets transcription factor Elf5 prevented formation of the secretory epithelium during pregnancy. Conversely, overexpression of Elf5 in an inducible transgenic model caused alveolar differentiation and milk secretion in virgin mice, disrupting ductal morphogenesis. CD61+ luminal progenitor cells accumulated in Elf5-deficient mammary glands and were diminished in glands with Elf5 overexpression. Thus Elf5 specifies the differentiation of CD61+ progenitors to establish the secretory alveolar lineage during pregnancy, providing a link between prolactin, transcriptional events, and alveolar development.
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Self-citationGATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland
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Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning
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Cited by
Lim, E., Wu, D., Pal, B., Bouras, T., Asselin-Labat, M.-L., Vaillant, F., Yagita, H., Lindeman, G. J., Smyth, G. K., & Visvader, J. E. (2010) · Breast Cancer Research · doi:10.1186/bcr2560 · Cited by 440
Self-citationThe ETS family of oncogenic transcription factors in solid tumours
Sizemore, G. M., Pitarresi, J. R., Balakrishnan, S., & Ostrowski, M. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.20 · Cited by 367
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland
Shehata, M., Teschendorff, A., Sharp, G., Novcic, N., Russell, I. A., Avril, S., Prater, M., Eirew, P., Caldas, C., Watson, C. J., et al. (2012) · Breast Cancer Research · doi:10.1186/bcr3334 · Cited by 306
Stem Cells and the Differentiation Hierarchy in Mammary Gland Development
Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2018 · Cited by 267
Self-citationProgesterone signalling in breast cancer: a neglected hormone coming into the limelight
Brisken, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3518 · Cited by 255
Metadata
- Authors
- Oakes, S. R., Naylor, M. J., Asselin-Labat, M.-L., Blazek, K. D., Gardiner-Garden, M., Hilton, H. N., Kazlauskas, M., Pritchard, M. A., Chodosh, L. A., Pfeffer, P. L., Lindeman, G. J., Visvader, J. E., & Ormandy, C. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-03-01
- Volume
- 22
- Issue
- 5
- Pages
- 581-586
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2019171053
- Cited by
- 260
- References
- 19
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: The Ets transcription factor Elf5 specifies mammary alveolar cell fate. https://app.cochat.ai/papers/10.1101/gad.1614608
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- Oakes, S. R., Naylor, M. J., Asselin-Labat, M.-L., Blazek, K. D., Gardiner-Garden, M., Hilton, H. N., Kazlauskas, M., Pritchard, M. A., Chodosh, L. A., Pfeffer, P. L., Lindeman, G. J., Visvader, J. E., & Ormandy, C. J. (2008). The Ets transcription factor Elf5 specifies mammary alveolar cell fate. Genes & Development. https://doi.org/10.1101/gad.1614608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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