The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development
Open accessAbstract
Bone morphogenic proteins 2 and 4 (BMP2 and BMP4) inhibit proliferation and induce differentiation of cerebellar granule neuron progenitors (GNPs) and primary GNP-like medulloblastoma (MB) cells. This occurs through rapid proteasome-mediated degradation of Math1 (Atoh1), a transcription factor expressed in proliferating GNPs. Ectopic expression of Atoh1, but not of Sonic hedgehog (Shh)-regulated Gli1 or Mycn, cancels these BMP-mediated effects and restores Shh-dependent proliferation of GNPs and MB cells in vitro and in vivo. Genes regulating the BMP signaling pathway are down-regulated in mouse MBs. Thus, BMPs are potent inhibitors of MB and should be considered as novel therapeutic agents.
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Cites
Math1-driven GFP expression in the developing nervous system of transgenic mice
Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N., et al. (2003) · Gene Expression Patterns · doi:10.1016/s1567-133x(03)00089-9 · Cited by 292
Cited by
Canettieri, G., Di Marcotullio, L., Greco, A., Coni, S., Antonucci, L., Infante, P., Pietrosanti, L., De Smaele, E., Ferretti, E., Miele, E., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2013 · Cited by 322
Development of the cerebellum: simple steps to make a ‘little brain’
Butts, T., Green, M. J., & Wingate, R. J. T. (2014) · Development · doi:10.1242/dev.106559 · Cited by 239
Metadata
- Authors
- Zhao, H., Ayrault, O., Zindy, F., Kim, J.-H., & Roussel, M. F.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-03-15
- Volume
- 22
- Issue
- 6
- Pages
- 722-727
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2020603167
- Cited by
- 170
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Zhao, H., Ayrault, O., Zindy, F., Kim, J.-H., & Roussel, M. F. (2008). Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes & Development. https://doi.org/10.1101/gad.1636408
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