Math1-driven GFP expression in the developing nervous system of transgenic mice
Abstract
Math1 is a bHLH transcription factor expressed in neural progenitor cells in multiple regions of the nervous system. Previously we identified a Math1 enhancer that directs expression of reporter genes in a Math1 specific pattern [Development 127 (2000) 1185]. We have used a portion of this enhancer to drive expression of a nuclear GFP reporter in the Math1 lineage in transgenic mice. In this transgenic mouse strain, GFP is expressed in Math1 domains in the (1). developing spinal cord in progenitors to dI1 dorsal interneurons, (2). granule-cell progenitors in the developing cerebellum, (3). Merkel cells in the skin, and (4). hair cells in the developing vestibular and auditory systems. Furthermore, non-Math1 related expression is detected that is likely due to the absence of inhibitory regulatory sequences from the transgene. These expression domains include (1). the apical ectodermal ridge in developing limbs, (2). post-mitotic cells in the developing cortex and spinal cord, (3). the dentate gyrus, (4). retina, and (5). olfactory epithelium. Because GFP marks specific neuronal cell types in living tissue, this transgenic strain is a powerful tool for future studies on the development and electrophysiological properties of distinct cell types in the central nervous system and in sensory systems.
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SOX2+ nuclei speckles in the skin epithelium were Atoh1/nGFP+ ISL1+ cells that arose in the epithelium between days 14-16, reminiscent of Merkel cells.
“Moreover, as mentioned earlier in Figure 4D′, the SOX2+ nuclei speckles in the skin epithelium were Atoh1/nGFP+ ISL1+ cells that arose in the epithelium between days 14–16 (Figure 5F–F″), reminiscence of Merkel cells, which are touch sensing cells in the epidermis (Lumpkin et al., 2003; Perdigoto et al., 2014).”
From Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids (2018) · cites this paper as Lumpkin et al., 2003
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Self-citation
- Authors
- Lumpkin, E. A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N., & Johnson, J. E.
- Affiliations
- University of California, San Francisco (US)
- The University of Texas Southwestern Medical Center (US)
- House Clinic (US)
- Corresponding author
- Johnson, Jane E.
- Venue
- Gene Expression Patterns
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 3
- Issue
- 4
- Pages
- 389-395
- ISSN
- 1567-133X (ISSN-L)
- OpenAlex
- W1994624028
- Cited by
- 292
- References
- 30
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 13 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 15 · 2017: 13 · 2016: 14 · 2015: 20 · 2014: 18 · 2013: 18 · 2012: 17
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene Expression Patterns (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC004189)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- Math1, bHLH transcription factors, GFP reporter, transgenic mice, neural progenitor cells, dorsal interneurons, granule cell progenitors, cerebellum, Merkel cells, hair cells, vestibular system, auditory system, apical ectodermal ridge, dentate gyrus, retina, olfactory epithelium, brain development
- MeSH terms
- Animals, Cerebellum, Female, Interneurons, Lac Operon, Luminescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Pregnancy, Skin, Spinal Cord, Transcription Factors, In Situ Hybridization, Gene Expression Regulation, Developmental, Merkel Cells, Green Fluorescent Proteins, Mice, Basic Helix-Loop-Helix Proteins
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