Regulation of SIRT1 activity by genotoxic stress
Open accessAbstract
SIRT1 regulates a variety of cellular functions, including cellular stress responses and energy metabolism. SIRT1 activity is negatively regulated by DBC1 (Deleted in Breast Cancer 1) through direct binding. However, how the DBC1–SIRT1 interaction is regulated remains unclear. We found that the DBC1–SIRT1 interaction increases following DNA damage and oxidative stress. The stress-induced DBC1–SIRT1 interaction requires the ATM-dependent phosphorylation of DBC1 at Thr 454, which creates a second binding site for SIRT1. Finally, we showed that the stress-induced DBC1–SIRT1 interaction is important for cell fate determination following genotoxic stress. These results revealed a novel mechanism of SIRT1 regulation during genotoxic stress.
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Ionizing radiation induced cell death after SIRT1 depletion.
“it induced cell death after SIRT1-depletion (not shown), as reported”
From Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype (2016) · cites this paper as Yuan et al., 2012
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- Authors
- Yuan, J., Luo, K., Liu, T., & Lou, Z.
- Affiliations
- Tongji University (CN)
- Mayo Clinic (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-03-30
- Volume
- 26
- Issue
- 8
- Pages
- 791-796
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3337453
- OpenAlex
- W2155046944
- Cited by
- 79
- References
- 34
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 19 · 2012: 3
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81101514)
- Science and Technology Commission of Shanghai Municipality
- National Institutes of Health
- National Cancer Institute (CA129344, R01CA130996, R01CA129344, CA130996)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- SIRT1, DBC1, genotoxic stress, DNA damage, oxidative stress, ATM phosphorylation, protein-protein interaction, cell fate determination, stress response, energy metabolism
- MeSH terms
- Binding Sites, DNA-Binding Proteins, Humans, Phosphorylation, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Cell Line, Tumor, Adaptor Proteins, Signal Transducing, Sirtuin 1, Ataxia Telangiectasia Mutated Proteins
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