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The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon.
Open accessAbstract
Mutations at the suppressor of Hairy-wing [su(Hw), 3-54.8] locus reverse the phenotype of second-site mutations induced by the gypsy transposable element in Drosophila melanogaster. This gene encodes a protein with a predicted molecular weight of 109,000 that contains an acidic domain and 12 copies of the DNA-binding 'Zn finger' motif. The su(Hw) protein was overexpressed in Escherichia coli and Drosophila cells, and partially purified. It was shown to interact specifically in vitro with a 367-bp DNA fragment that contains 12 copies of the sequence PyPuTTGCATACCPy located in the 5'-untranslated region of gypsy, between the 5' long terminal repeat (LTR) and the first ATG initiation codon. This sequence shows striking homology to some mammalian transcriptional enhancer elements, supporting a role for the su(Hw) protein in the control of gypsy transcription. In addition, the su(Hw) protein is present at approximately 100-200 sites on Drosophila polytene chromosomes, suggesting that it also interacts in vivo with DNA and might be involved functionally in the regulation of normal cellular genes.
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Citations
Cited by
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Pfeiffer, B. D., Ngo, T.-T. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010) · Genetics · doi:10.1534/genetics.110.119917 · Cited by 1,153
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
Bell, A. C., West, A. G., & Felsenfeld, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81967-4 · Cited by 1,101
Insulators: many functions, many mechanisms
West, A. G., Gaszner, M., & Felsenfeld, G. (2002) · Genes & Development · doi:10.1101/gad.954702 · Cited by 631
DNA position-specific repression of transcription by a Drosophila zinc finger protein.
Geyer, P. K., & Corces, V. G. (1992) · Genes & Development · doi:10.1101/gad.6.10.1865 · Cited by 422
Self-citationCharacterization of the chicken β-globin insulator
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Metadata
- Authors
- Spana, C., Harrison, D. A., & Corces, V. G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1988-11
- Volume
- 2
- Issue
- 11
- Pages
- 1414-1423
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2004060771
- Cited by
- 195
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon. https://app.cochat.ai/papers/10.1101/gad.2.11.1414
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- Spana, C., Harrison, D. A., & Corces, V. G. (1988). The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon. Genes & Development. https://doi.org/10.1101/gad.2.11.1414
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