The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Characterization of the chicken β-globin insulator
Open accessAbstract
Insulators, first identified in Drosophila , are DNA sequence elements that shield a promoter from nearby regulatory elements. We have previously reported that a DNA sequence at the 5′ end of the chicken β-globin locus can function as an insulator. It is capable of shielding a reporter gene from the activating effects of a nearby mouse β-globin locus control region element in the human erythroleukemic cell line K562. In this report, we show that most of the insulating activity lies in a 250-bp CpG island (core element), which contains the constitutive DNase I-hypersensitive site (5′HS4). DNA binding assays with the core sequence reveal a complex protein binding pattern. The insulating activity of the core element is multiplied when tandem copies are used. Although CpG islands are often associated with promoters of housekeeping genes, we find little evidence that the core element is a promoter. Furthermore, the insulator differs from a promoter in its ability to block the locus control region effect directionally.
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Cites
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Cited by
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
Bell, A. C., & Felsenfeld, G. (2000) · Nature · doi:10.1038/35013100 · Cited by 1,746
Self-citationMadisen, L., Garner, A. R., Shimaoka, D., Chuong, A. S., Klapoetke, N. C., Li, L., van der Bourg, A., Niino, Y., Egolf, L., Monetti, C., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.022 · Cited by 1,114
The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
Bell, A. C., West, A. G., & Felsenfeld, G. (1999) · Cell · doi:10.1016/s0092-8674(00)81967-4 · Cited by 1,101
Self-citationInsulators: exploiting transcriptional and epigenetic mechanisms
Gaszner, M., & Felsenfeld, G. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1925 · Cited by 649
Self-citationInappropriate Gene Activation in FSHD
Gabellini, D., Green, M. R., & Tupler, R. (2002) · Cell · doi:10.1016/s0092-8674(02)00826-7 · Cited by 400
Metadata
- Authors
- Chung, J. H., Bell, A. C., & Felsenfeld, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-01-21
- Volume
- 94
- Issue
- 2
- Pages
- 575-580
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2094595339
- Cited by
- 386
- References
- 20
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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