The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates.
Open accessAbstract
Delta (D1) is required for normal segregation of the embryonic ectoderm into neural and epidermal cell lineages in Drosophila melanogaster. Loss-of-function mutations in D1 and other zygotic neurogenic loci lead to expansion of the neuroblast population at the expense of the dermoblast population within the ectoderm. Characterization of the transcriptional organization and maternal/embryonic expression within the chromosomal interval corresponding to D1 reveals that the locus encodes multiple transcripts: a minimum of two maternal transcripts, approximately 4.5 and 3.6 kb in length, and four zygotic transcripts, approximately 5.4 (two distinct species), 3.5, and 2.8 kb in length. These transcripts differ on the bases of differential splicing and differential polyadenylation site choice. The DNA sequence of a cDNA clone representing the predominant transcripts of the locus indicates that D1 encodes a transmembrane protein homologous to blood coagulation factors and epidermal growth factor. The relationship between coding sequences and transcript-specific exons within the locus suggests that D1 encodes multiple translational products.
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Ny, T., Elgh, F., & Lund, B. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.17.5355 · Cited by 299
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Parks, A. L., Klueg, K. M., Stout, J. R., & Muskavitch, M. A. T. (2000) · Development · doi:10.1242/dev.127.7.1373 · Cited by 494
Self-citationBettenhausen, B., Hrabê de Angelis, M., Simon, D., Guénet, J.-L., & Gossler, A. (1995) · Development · doi:10.1242/dev.121.8.2407 · Cited by 451
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Metadata
- Authors
- Kopczynski, C. C., Alton, A. K., Fechtel, K., Kooh, P. J., & Muskavitch, M. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1988-12-01
- Volume
- 2
- Issue
- 12b
- Pages
- 1723-1735
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2094690446
- Cited by
- 245
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kopczynski, C. C., Alton, A. K., Fechtel, K., Kooh, P. J., & Muskavitch, M. A. (1988). Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates. Genes & Development. https://doi.org/10.1101/gad.2.12b.1723
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