The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Notch2: a second mammalian Notch gene
Abstract
Notch is a cell surface receptor that mediates a wide variety of cellular interactions that specify cell fate during Drosophila development. Recently, homologs of Drosophila Notch have been isolated from Xenopus, human and rat, and the expression patterns of these ver- tebrate proteins suggest that they may be functionally analogous to their Drosophila counterpart. We have now identified a second rat gene that exhibits substantial nucleic and amino acid sequence identity to Drosophila Notch. This gene, designated Notch2, encodes a protein that contains all the structural motifs characteristic of a Notch protein. Thus, mammals differ from Drosophila in having more than one Notch gene. Northern and in situ hybridisation analyses in the developing and adult rat identify distinct spatial and temporal patterns of expression for Notch1 and Notch2, indicating that these genes are not redundant. These results suggest that the great diversity of cell-fate decisions regulated by Notch in Drosophila may be further expanded in vertebrates by the activation of distinct Notch proteins.
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Cites
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Cited by
Expression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
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Notch1 is essential for postimplantation development in mice.
Swiatek, P. J., Lindsell, C. E., del Amo, F. F., Weinmaster, G., & Gridley, T. (1994) · Genes & Development · doi:10.1101/gad.8.6.707 · Cited by 734
Self-citationConservation of the Notch signalling pathway in mammalian neurogenesis
Luis de la Pompa, J., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., et al. (1997) · Development · doi:10.1242/dev.124.6.1139 · Cited by 624
Geling, A., Steiner, H., Willem, M., Bally‐Cuif, L., & Haass, C. (2002) · The EMBO Reports · doi:10.1093/embo-reports/kvf124 · Cited by 497
Metadata
- Authors
- Weinmaster, G., Roberts, V. J., & Lemke, G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1992-12-01
- Volume
- 116
- Issue
- 4
- Pages
- 931-941
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2118623951
- Cited by
- 339
- References
- 62
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weinmaster, G., Roberts, V. J., & Lemke, G. (1992). Notch2: a second mammalian Notch gene. Development. https://doi.org/10.1242/dev.116.4.931
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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