The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.
Open accessAbstract
Human alpha- and beta-interferons (IFNs) stimulate rapid but transient increases in transcription from a set of previously quiescent genes. Protein synthesis is not required for initial stimulation, but duration of the response is limited to a few hours by a process requiring synthesis of new proteins. An IFN-stimulated response element (ISRE) was identified 5' to an inducible gene by deletion analysis and point mutagenesis, and sequence comparisons with other promoters defined the consensus element YAGTTTC(A/T)YTTTYCC. Two classes of IFN-inducible nuclear factors were found that bind to the ISRE. The most rapidly induced factor appeared without new protein synthesis, whereas a second factor required active protein synthesis for its appearance and maintenance. The kinetics of appearance and loss of these binding activities correlate with the activation and repression of IFN-stimulated genes. These different IFN-activated or induced factors may bind sequentially to the same essential promoter element to first increase and then repress transcription.
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Cites
Fisher, D. A., Hunt, S. W., & Hood, L. (1985) · The Journal of experimental medicine · doi:10.1084/jem.162.2.528 · Cited by 109
Cited by
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Self-citationInterferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
Schindler, C., Shuai, K., Prezioso, V. R., & Darnell, J. E. (1992) · Science · doi:10.1126/science.1496401 · Cited by 899
A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors
Sadowski, H. B., Shuai, K., Darnell, J. E., & Gilman, M. Z. (1993) · Science · doi:10.1126/science.8397445 · Cited by 699
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Metadata
- Authors
- Levy, D. E., Kessler, D. S., Pine, R., Reich, N., & Darnell, J. E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1988-04
- Volume
- 2
- Issue
- 4
- Pages
- 383-393
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2171759277
- Cited by
- 559
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Levy, D. E., Kessler, D. S., Pine, R., Reich, N., & Darnell, J. E. (1988). Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes & Development. https://doi.org/10.1101/gad.2.4.383
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
