The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors
Abstract
Growth factors and cytokines act through cell surface receptors with different biochemical properties. Yet each type of receptor can elicit similar as well as distinct biological responses in target cells, suggesting that distinct classes of receptors activate common gene sets. Epidermal growth factor, interferon-γ, and interleukin-6 all activated, through direct tyrosine phosphorylation, latent cytoplasmic transcription factors that recognized similar DNA elements. However, different ligands activated different patterns of factors with distinct DNA-binding specificities in the same and different cells. Thus, unrelated receptors may activate a common nuclear signal transduction pathway that, through differential use of latent cytoplasmic proteins, permits these receptors to regulate both common and unique sets of genes.
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Citations
Cites
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The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
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PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS
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Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor
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Self-citationA protein tyrosine kinase in the interferon αβ signaling pathway
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Cited by
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Self-citationDarnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979
Self-citationMarshall, C. J. (1995) · Cell · doi:10.1016/0092-8674(95)90401-8 · Cited by 3,906
Zhong, Z., Wen, Z., & Darnell, J. E. (1994) · Science · doi:10.1126/science.8140422 · Cited by 2,070
Self-citationDimerization of cell surface receptors in signal transduction
Heldin, C.-H. (1995) · Cell · doi:10.1016/0092-8674(95)90404-2 · Cited by 1,634
Metadata
- Authors
- Sadowski, H. B., Shuai, K., Darnell, J. E., & Gilman, M. Z.
- Venue
- Science
- Published
- 1993-09-24
- Volume
- 261
- Issue
- 5129
- Pages
- 1739-1744
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2034974668
- Cited by
- 699
- References
- 41
- FWCI
- 41.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sadowski, H. B., Shuai, K., Darnell, J. E., & Gilman, M. Z. (1993). A Common Nuclear Signal Transduction Pathway Activated by Growth Factor and Cytokine Receptors. Science. https://doi.org/10.1126/science.8397445
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
