The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nuclear factor I/B is an oncogene in small cell lung cancer
Open accessAbstract
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.
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Self-citationRecurring mutations found by sequencing an acute myeloid leukemia genome
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Metadata
- Authors
- Dooley, A. L., Winslow, M. M., Chiang, D. Y., Banerji, S., Stransky, N., Dayton, T. L., Snyder, E. L., Senna, S., Whittaker, C. A., Bronson, R. T., Crowley, D., Barretina, J., Garraway, L., Meyerson, M., & Jacks, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2011-07-15
- Volume
- 25
- Issue
- 14
- Pages
- 1470-1475
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2150329946
- Cited by
- 174
- References
- 8
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Nuclear factor I/B is an oncogene in small cell lung cancer. https://app.cochat.ai/papers/10.1101/gad.2046711
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- Dooley, A. L., Winslow, M. M., Chiang, D. Y., Banerji, S., Stransky, N., Dayton, T. L., Snyder, E. L., Senna, S., Whittaker, C. A., Bronson, R. T., Crowley, D., Barretina, J., Garraway, L., Meyerson, M., & Jacks, T. (2011). Nuclear factor I/B is an oncogene in small cell lung cancer. Genes & Development. https://doi.org/10.1101/gad.2046711
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