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Functional and molecular features of the Id4 + germline stem cell population in mouse testes
Open accessAbstract
The maintenance of cycling cell lineages relies on undifferentiated subpopulations consisting of stem and progenitor pools. Features that delineate these cell types are undefined for many lineages, including spermatogenesis, which is supported by an undifferentiated spermatogonial population. Here, we generated a transgenic mouse line in which spermatogonial stem cells are marked by expression of an inhibitor of differentiation 4 ( Id4 ) -green fluorescent protein ( Gfp ) transgene. We found that Id4-Gfp + cells exist primarily as a subset of the type A single pool, and their frequency is greatest in neonatal development and then decreases in proportion during establishment of the spermatogenic lineage, eventually comprising ∼2% of the undifferentiated spermatogonial population in adulthood. RNA sequencing analysis revealed that expression of 11 and 25 genes is unique for the Id4-Gfp + /stem cell and Id4-Gfp − /progenitor fractions, respectively. Collectively, these findings provide the first definitive evidence that stem cells exist as a rare subset of the A single pool and reveal transcriptome features distinguishing stem cell and progenitor states within the mammalian male germline.
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Cites
Identification of stem cells in small intestine and colon by marker gene Lgr5
Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687
Cited by
Spermatogenesis: The Commitment to Meiosis
Griswold, M. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00013.2015 · Cited by 825
A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq
Green, C. D., Ma, Q., Manske, G. L., Shami, A. N., Zheng, X., Marini, S., Moritz, L., Sultan, C., Gurczynski, S. J., Moore, B. B., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.025 · Cited by 521
The nature and dynamics of spermatogonial stem cells
de Rooij, D. G. (2017) · Development · doi:10.1242/dev.146571 · Cited by 313
Metadata
- Authors
- Chan, F., Oatley, M. J., Kaucher, A. V., Yang, Q.-E., Bieberich, C. J., Shashikant, C. S., & Oatley, J. M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-06-15
- Volume
- 28
- Issue
- 12
- Pages
- 1351-1362
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2150552014
- Cited by
- 231
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Chan, F., Oatley, M. J., Kaucher, A. V., Yang, Q.-E., Bieberich, C. J., Shashikant, C. S., & Oatley, J. M. (2014). Functional and molecular features of the Id4 + germline stem cell population in mouse testes. Genes & Development. https://doi.org/10.1101/gad.240465.114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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