The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production
Open accessAbstract
Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation in the embryo will guide efforts to produce and expand HSPCs ex vivo. Here we show that sterile tonic inflammatory signaling regulates embryonic HSPC formation. Expression profiling of progenitors with lymphoid potential and hematopoietic stem cells (HSCs) from aorta/gonad/mesonephros (AGM) regions of midgestation mouse embryos revealed a robust innate immune/inflammatory signature. Mouse embryos lacking interferon γ (IFN-γ) or IFN-α signaling and zebrafish morphants lacking IFN-γ and IFN-ϕ activity had significantly fewer AGM HSPCs. Conversely, knockdown of IFN regulatory factor 2 (IRF2), a negative regulator of IFN signaling, increased expression of IFN target genes and HSPC production in zebrafish. Chromatin immunoprecipitation (ChIP) combined with sequencing (ChIP-seq) and expression analyses demonstrated that IRF2-occupied genes identified in human fetal liver CD34+HSPCs are actively transcribed in human and mouse HSPCs. Furthermore, we demonstrate that the primitive myeloid population contributes to the local inflammatory response to impact the scale of HSPC production in the AGM region. Thus, sterile inflammatory signaling is an evolutionarily conserved pathway regulating the production of HSPCs during embryonic development.
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Cites
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IFNα activates dormant haematopoietic stem cells in vivo
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Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection
Baldridge, M. T., King, K. Y., Boles, N. C., Weksberg, D. C., & Goodell, M. A. (2010) · Nature · doi:10.1038/nature09135 · Cited by 877
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence
Yoshimoto, M., Porayette, P., Glosson, N. L., Conway, S. J., Carlesso, N., Cardoso, A. A., Kaplan, M. H., & Yoder, M. C. (2012) · Blood · doi:10.1182/blood-2011-12-397489 · Cited by 178
Cited by
Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3346 · Cited by 689
Inflammation: a key regulator of hematopoietic stem cell fate in health and disease
Pietras, E. M. (2017) · Blood · doi:10.1182/blood-2017-06-780882 · Cited by 417
Bauer, D. E., & Orkin, S. H. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.08.001 · Cited by 143
Self-citationHematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands
Kasbekar, M., Mitchell, C. A., Proven, M. A., & Passegué, E. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.09.013 · Cited by 132
Inflammatory signaling regulates hematopoietic stem and progenitor cell development and homeostasis
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Yin and Yang: The dual effects of interferons on hematopoiesis
Demerdash, Y., Kain, B., Essers, M. A. G., & King, K. Y. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.02.002 · Cited by 76
Stress and non-stress roles of inflammatory signals during HSC Emergence and maintenance
Clapes, T., Lefkopoulos, S., & Trompouki, E. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00487 · Cited by 62
Non‐steady‐state hematopoiesis regulated by the C/EBP β transcription factor
Hirai, H., Yokota, A., Tamura, A., Sato, A., & Maekawa, T. (2015) · Cancer Science · doi:10.1111/cas.12690 · Cited by 57
Dumetier, B., Sauter, C., Hajmirza, A., Pernon, B., Aucagne, R., Fournier, C., Row, C., Guidez, F., Rossi, C., Lepage, C., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10123101 · Cited by 9
Metadata
- Authors
- Li, Y., Esain, V., Teng, L., Xu, J., Kwan, W., Frost, I. M., Yzaguirre, A. D., Cai, X., Cortes, M., Maijenburg, M. W., Tober, J., Dzierzak, E., Orkin, S. H., Tan, K., North, T. E., & Speck, N. A.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-11-13
- Volume
- 28
- Issue
- 23
- Pages
- 2597-2612
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2022942001
- Cited by
- 261
- References
- 6
- Type
- posted content
- Language
- en
- Open access
- diamond
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