The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The Polycomb -group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1
Open accessAbstract
The Polycomb -group (PcG) proteins MEDEA, FERTILIZATION INDEPENDENT ENDOSPERM, and FERTILIZATION INDEPENDENT SEED2 regulate seed development in Arabidopsis by controlling embryo and endosperm proliferation. All three of these FIS-class proteins are likely subunits of a multiprotein PcG complex, which epigenetically regulates downstream target genes that were previously unknown. Here we show that the MADS-box gene PHERES1 ( PHE1 ) is commonly deregulated in the fis -class mutants. PHE1 belongs to the evolutionarily ancient type I class of MADS-box proteins that have not yet been assigned any function in plants. Both MEDEA and FIE directly associate with the promoter region of PHE1 , suggesting that PHE1 expression is epigenetically regulated by PcG proteins. PHE1 is expressed transiently after fertilization in both the embryo and the endosperm; however, it remains up-regulated in the fis mutants, consistent with the proposed function of the FIS genes as transcriptional repressors. Reduced expression levels of PHE1 in medea mutant seeds can suppress medea seed abortion, indicating a key role of PHE1 repression in seed development. PHE1 expression in a hypomethylated medea mutant background resembles the wild-type expression pattern and is associated with rescue of the medea seed-abortion phenotype. In summary, our results demonstrate that seed abortion in the medea mutant is largely mediated by deregulated expression of the type I MADS-box gene PHE1 .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Assaying chimeric genes in plants: The GUS gene fusion system
Jefferson, R. A. (1987) · Plant Molecular Biology Reporter · doi:10.1007/bf02667740 · Cited by 4,486
Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex
Müller, J., Hart, C. M., Francis, N. J., Vargas, M. L., Sengupta, A., Wild, B., Miller, E. L., O'Connor, M. B., Kingston, R. E., & Simon, J. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00976-5 · Cited by 1,562
Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., & Pirrotta, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00975-3 · Cited by 1,533
Maternal Control of Embryogenesis by MEDEA , a Polycomb Group Gene in Arabidopsis
Grossniklaus, U., Vielle-Calzada, J.-P., Hoeppner, M. A., & Gagliano, W. B. (1998) · Science · doi:10.1126/science.280.5362.446 · Cited by 849
Self-citationA Polycomb-group gene regulates homeotic gene expression in Arabidopsis
Goodrich, J., Puangsomlee, P., Martin, M., Long, D., Meyerowitz, E. M., & Coupland, G. (1997) · Nature · doi:10.1038/386044a0 · Cited by 829
Arabidopsis thaliana DNA Methylation Mutants
Vongs, A., Kakutani, T., Martienssen, R. A., & Richards, E. J. (1993) · Science · doi:10.1126/science.8316832 · Cited by 706
Maintenance of genomic methylation requires a SWI2/SNF2-like protein
Jeddeloh, J. A., Stokes, T. L., & Richards, E. J. (1999) · Nature Genetics · doi:10.1038/8803 · Cited by 705
The VERNALIZATION 2 Gene Mediates the Epigenetic Regulation of Vernalization in Arabidopsis
Gendall, A. R., Levy, Y. Y., Wilson, A., & Dean, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00573-6 · Cited by 616
An ancestral MADS-box gene duplication occurred before the divergence of plants and animals
Alvarez-Buylla, E. R., Pelaz, S., Liljegren, S. J., Gold, S. E., Burgeff, C., Ditta, G. S., Ribas de Pouplana, L., Martínez-Castilla, L., & Yanofsky, M. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5328 · Cited by 577
Interplay between Two Epigenetic Marks
Johnson, L. M., Cao, X., & Jacobsen, S. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00976-4 · Cited by 474
Cited by
Molecular networks regulating Arabidopsis seed maturation, after‐ripening, dormancy and germination
Holdsworth, M. J., Bentsink, L., & Soppe, W. J. J. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02437.x · Cited by 964
Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis
Zhang, X., Clarenz, O., Cokus, S., Bernatavichute, Y. V., Pellegrini, M., Goodrich, J., & Jacobsen, S. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050129 · Cited by 767
Nuclear Endosperm Development in Cereals and Arabidopsis thaliana
Olsen, O.-A. (2004) · THE PLANT CELL ONLINE · doi:10.1105/tpc.017111 · Cited by 490
Kohler, C. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg444 · Cited by 454
Female Gametophyte Development
Yadegari, R. (2004) · THE PLANT CELL ONLINE · doi:10.1105/tpc.018192 · Cited by 451
Metadata
- Authors
- Köhler, C., Hennig, L., Spillane, C., Pien, S., Gruissem, W., & Grossniklaus, U.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-06-15
- Volume
- 17
- Issue
- 12
- Pages
- 1540-1553
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2097547758
- Cited by
- 425
- References
- 36
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Polycomb -group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1. https://app.cochat.ai/papers/10.1101/gad.257403
- The paper
- Köhler, C., Hennig, L., Spillane, C., Pien, S., Gruissem, W., & Grossniklaus, U. (2003). The Polycomb -group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1. Genes & Development. https://doi.org/10.1101/gad.257403
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
