The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Arabidopsis thaliana DNA Methylation Mutants
Abstract
Three DNA hypomethylation mutants of the flowering plant Arabidopsis thaliana were isolated by screening mutagenized populations for plants containing centromeric repetitive DNA arrays susceptible to digestion by a restriction endonuclease that was sensitive to methylated cytosines. The mutations are recessive, and at least two are alleles of a single locus, designated DDM1 (for decrease in DNA methylation). Amounts of 5-methylcytosine were reduced over 70 percent in ddm1 mutants. Despite this reduction in DNA methylation levels, ddm1 mutants developed normally and exhibited no striking morphological phenotypes. However, the ddm1 mutations are associated with a segregation distortion phenotype. The ddm1 mutations were used to demonstrate that de novo DNA methylation in vivo is slow.
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
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Slotkin, R. K., Vaughn, M., Borges, F., Tanurdžić, M., Becker, J. D., Feijó, J. A., & Martienssen, R. A. (2009) · Cell · doi:10.1016/j.cell.2008.12.038 · Cited by 946
Self-citationRequirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation
Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., & Jacobsen, S. E. (2001) · Science · doi:10.1126/science.1059745 · Cited by 938
Comprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome
Stroud, H., Greenberg, M. V. C., Feng, S., Bernatavichute, Y. V., & Jacobsen, S. E. (2013) · Cell · doi:10.1016/j.cell.2012.10.054 · Cited by 873
Assessing the Impact of Transgenerational Epigenetic Variation on Complex Traits
Johannes, F., Porcher, E., Teixeira, F. K., Saliba-Colombani, V., Simon, M., Agier, N., Bulski, A., Albuisson, J., Heredia, F., Audigier, P., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000530 · Cited by 814
Jüttermann, R., Li, E., & Jaenisch, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11797 · Cited by 678
Metadata
- Authors
- Vongs, A., Kakutani, T., Martienssen, R. A., & Richards, E. J.
- Venue
- Science
- Published
- 1993-06-25
- Volume
- 260
- Issue
- 5116
- Pages
- 1926-1928
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052639867
- Cited by
- 706
- References
- 2
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vongs, A., Kakutani, T., Martienssen, R. A., & Richards, E. J. (1993). Arabidopsis thaliana DNA Methylation Mutants. Science. https://doi.org/10.1126/science.8316832
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