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Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
Open accessAbstract
S N 1-type alkylating agents represent an important class of chemotherapeutics, but the molecular mechanisms underlying their cytotoxicity are unknown. Thus, although these substances modify predominantly purine nitrogen atoms, their toxicity appears to result from the processing of O6-methylguanine (6Me G)-containing mispairs by the mismatch repair (MMR) system, because cells with defective MMR are highly resistant to killing by these agents. In an attempt to understand the role of the MMR system in the molecular transactions underlying the toxicity of alkylating agents, we studied the response of human MMR-proficient and MMR-deficient cells to low concentrations of the prototypic methylating agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). We now show that MNNG treatment induced a cell cycle arrest that was absolutely dependent on functional MMR. Unusually, the cells arrested only in the second G 2 phase after treatment. Downstream targets of both ATM (Ataxia telangiectasia mutated) and ATR (ATM and Rad3-related) kinases were modified, but only the ablation of ATR, or the inhibition of CHK1, attenuated the arrest. The checkpoint activation was accompanied by the formation of nuclear foci containing the signaling and repair proteins ATR, the S*/T*Q substrate, γ-H2AX, and replication protein A (RPA). The persistence of these foci implied that they may represent sites of irreparable damage.
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“MLH1 is also required for MNNG-induced ATR checkpoint activation such as Chk1 phosphorylation and the colocalization of γ-H2AX and RPA [213]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [213]
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Cites
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466
Oxidative DNA damage: mechanisms, mutation, and disease
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245
Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
ATM and related protein kinases: safeguarding genome integrity
Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
Rogakou, E. P., Boon, C., Redon, C., & Bonner, W. M. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.5.905 · Cited by 2,422
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M., & Bonner, W. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00610-2 · Cited by 2,098
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
Falck, J., Mailand, N., Syljuåsen, R. G., Bartek, J., & Lukas, J. (2001) · Nature · doi:10.1038/35071124 · Cited by 1,085
(1999) · PubMed · Cited by 1,030
Flagged first, then by citations
Research works printed but not linked: 7
- 2000, Cancer Res., 60, 2108
- 2003, Cancer Res., 63, 8158
- 1995, Cancer Res., 55, 3721
- 1999, Cancer Res., 59, 4375
- 1997, Cancer Res., 57, 3949
- 2001, Cancer Res., 61, 8554
- 2003, Clin. Cancer Res., 9, 2327
Cited by
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Items 101–200 of 246
Kim, W.-J., Rajasekaran, B., & Brown, K. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701451200 · Cited by 40
Deinzer, C. K. W., Danova, D., Kleb, B., KLOSE, K. J., & Heverhagen, J. T. (2014) · Contrast Media & Molecular Imaging · doi:10.1002/cmmi.1567 · Cited by 39
Jiang, Z., Jin, S., Yalowich, J. C., Brown, K. D., & Rajasekaran, B. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0627 · Cited by 38
Strong Hereditary Predispositions to Colorectal Cancer
Hryhorowicz, S., Kaczmarek-Ryś, M., Lis, E., Porowski, J., Szuman, M., Grot, N., Kryszczyńska, A., Paszkowski, J., Banasiewicz, T., & Pławski, A. (2022) · Genes · doi:10.3390/genes13122326 · Cited by 38
Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis
Sanada, M., Hidaka, M., Takagi, Y., Takano, T. Y., Nakatsu, Y., Tsuzuki, T., & Sekiguchi, M. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm188 · Cited by 37
Human Pluripotent Stem Cells Have a Novel Mismatch Repair-dependent Damage Response
Lin, B., Gupta, D., & Heinen, C. D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.570937 · Cited by 35
Biochemical Analysis of the Human Mismatch Repair Proteins hMutSα MSH2G674A-MSH6 and MSH2-MSH6T1219D
Geng, H. Z., Sakato, M., DeRocco, V., Yamane, K., Du, C., Erie, D. A., Hingorani, M., & Hsieh, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316919 · Cited by 36
Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells
von Bueren, A. O., Shalaby, T., Rajtarova, J., Stearns, D. S., Eberhart, C. G., Helson, L., Arcaro, A., & Grotzer, M. A. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-19 · Cited by 35
Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots
Cao, X., Wang, H., Zhuang, D., Zhu, H., Du, Y., Cheng, Z., Cui, W., Rogers, H. J., Zhang, Q., Jia, C., et al. (2018) · Chemosphere · doi:10.1016/j.chemosphere.2018.03.017 · Cited by 35
Chromosome Missegregation Associated with RUVBL1 Deficiency
Gentili, C., Castor, D., Kaden, S., Lauterbach, D., Gysi, M., Steigemann, P., Gerlich, D. W., Jiricny, J., & Ferrari, S. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133576 · Cited by 36
Self-citationDNA Mismatch Repair-dependent Activation of c-Abl/p73α/GADD45α-mediated Apoptosis
Li, L. S., Morales, J. C., Hwang, A., Wagner, M. W., & Boothman, D. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709954200 · Cited by 34
BRCA1 Activates a G2-M Cell Cycle Checkpoint following 6-Thioguanine–Induced DNA Mismatch Damage
Yamane, K., Schupp, J. E., & Kinsella, T. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2205 · Cited by 33
Heinen, C. D., & Rasmussen, L. J. (2012) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-10-9 · Cited by 34
Wojciechowicz, K., Cantelli, E., van Gerwen, B., Plug, M., van der Wal, A., Delzenne‐Goette, E., Song, J., de Vries, S., Dekker, M., & Riele, H. T. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.052 · Cited by 31
Fujikane, R., Komori, K., Sekiguchi, M., & Hidaka, M. (2016) · Scientific Reports · doi:10.1038/srep31714 · Cited by 31
Ito, M., Ohba, S., Gaensler, K. M. L., Ronen, S. M., Mukherjee, J., & Pieper, R. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062351 · Cited by 31
Cui, B., Johnson, S. P., Bullock, N., Ali‐Osman, F., Bigner, D. D., & Friedman, H. S. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.053124 · Cited by 32
Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair
Cantor, S. B., & Xie, J. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20568 · Cited by 29
Role of c-Abl Kinase in DNA Mismatch Repair-dependent G2 Cell Cycle Checkpoint Arrest Responses
Wagner, M. W., Li, L. S., Morales, J. C., Galindo, C. L., Garner, H. R., Bornmann, W. G., & Boothman, D. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709953200 · Cited by 29
Chen, T., Jinlin, D., Wang, F., Yuan, Z., Xue, J., Lu, T., Huang, W., Liu, Y., & Zhang, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215692 · Cited by 28
CSA and CSB play a role in the response to DNA breaks
Pascucci, B., Fragale, A., Marabitti, V., Leuzzi, G., Calcagnile, A. S., Parlanti, E., Franchitto, A., Dogliotti, E., & D’Errico, M. (2018) · Oncotarget · doi:10.18632/oncotarget.24342 · Cited by 31
Bodakuntla, S., Anandi, L., V, Sural, S., Trivedi, P., & Lahiri, M. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-287 · Cited by 26
Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage
Mastrocola, A. S., & Heinen, C. D. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.11.003 · Cited by 26
Alvarez, D., Chou, C. J., Latella, L., Zeitlin, S. G., Ku, S., Puri, P., Dervan, P. B., & Gottesfeld, J. M. (2006) · Cell Cycle · doi:10.4161/cc.5.14.2913 · Cited by 26
Alvino, E., Passarelli, F., Cannavò, E., Fortes, C., Mastroeni, S., Caporali, S., Jiricny, J., Cappellini, G. C. A., Scoppola, A., Marchetti, P., et al. (2014) · American Journal of Clinical Pathology · doi:10.1309/ajcpcx2d9yulbblg · Cited by 26
Self-citationMastrocola, A. S., & Heinen, C. D. (2010) · Human Mutation · doi:10.1002/humu.21333 · Cited by 25
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Bai, H., Madabushi, A., Guan, X., & Lu, A.-L. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.011 · Cited by 25
REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY
Lynch, J. P., Metz, D. C., Schuppan, D., Junker, Y., & Barisani, D. (2009) · Cited by 24
Arora, S., Huwe, P. J., Sikder, R. K., Shah, M., Browne, A. J., Lesh, R. W., Nicolas, É., Deshpande, S., Hall, M. J., Dunbrack, R. L., et al. (2017) · Cancer Biology & Therapy · doi:10.1080/15384047.2017.1326439 · Cited by 26
RAD51D protects against MLH1-dependent cytotoxic responses to O6-methylguanine
Rajesh, P., Rajesh, C., Wyatt, M. D., & Pittman, D. L. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.009 · Cited by 23
Roesner, L. M., Mielke, C., Fähnrich, S., Merkhoffer, Y., Dittmar, K. E. J., Drexler, H. G., & Dirks, W. G. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24591 · Cited by 23
MLH1 mediates PARP-dependent cell death in response to the methylating agent N-methyl-N-nitrosourea
McDaid, J. R., Loughery, J., Dunne, P. D., Boyer, J. C., Downes, C. S., Farber, R. A., & Walsh, C. P. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605186 · Cited by 22
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Kampinga, H. H., & Laszlo, A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0006 · Cited by 23
Harris, M. O., Kallenberger, L., Borán, M. S., Enoiu, M., Costanzo, V., & Jiricny, J. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.01.014 · Cited by 21
Self-citationATM activation by a sulfhydryl‐reactive inflammatory cyclopentenone prostaglandin
Kobayashi, M., Ono, H., Mihara, K. L., Tauchi, H., Komatsu, K., Shibata, T., Shimizu, H., Uchida, K., & Yamamoto, K. (2006) · Genes to Cells · doi:10.1111/j.1365-2443.2006.00976.x · Cited by 22
Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos
Feitsma, H., Akay, A., & Cuppen, E. P. J. G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn341 · Cited by 20
Ghodgaonkar, M. M., Kehl, P. A., Ventura, I., Hu, L., Bignami, M., & Jiricny, J. (2014) · Nature Communications · doi:10.1038/ncomms5990 · Cited by 20
Self-citationHwang, T., Sitko, L. K., Khoirunnisa, R., Aguad, F. N., Samuel, D. M., Park, H., Cheon, B., Mutsnaini, L., Lee, J., Otlu, B., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1122 · Cited by 21
Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions
Tsaalbi‐Shtylik, A., Ferrás, C., Pauw, B., Hendriks, G., Temviriyanukul, P., Carlée, L., Calléja, F. M. G. R., van Hees‐Stuivenberg, S., Akagi, J., Iwai, S., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201408017 · Cited by 20
Histone/protein deacetylase SIRT1 is an anticancer therapeutic target.
Hwang, B., Madabushi, A., Jin, J., Lin, S.-Y., & Lu, A.-L. (2014) · PubMed Central · Cited by 18
Tails of histones in DNA double-strand break repair
Bilsland, E., & Downs, J. A. (2005) · Mutagenesis · doi:10.1093/mutage/gei031 · Cited by 19
Treatment of Pituitary Carcinomas and Atypical Pituitary Adenomas: A Review
HIROHATA, T., Ishii, Y., & Matsuno, A. (2014) · Neurologia medico-chirurgica · doi:10.2176/nmc.ra.2014-0178 · Cited by 16
Guo, S., Fang, J., Xu, W., Ortega, J., Liu, C.-Y., Gu, L., Chang, Z., & Li, G. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102102 · Cited by 19
Biological Basis for Threshold Responses to Methylating Agents
Thomas, A. D. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00052 · Cited by 16
Interplay of DNA Repair Pathways Controls Methylation Damage Toxicity in Saccharomyces cerevisiae
Ćejka, P., & Jiricny, J. (2008) · Genetics · doi:10.1534/genetics.108.089979 · Cited by 15
Self-citationWielders, E., Hettinger, J., Dekker, R., Kets, C. M., Ligtenberg, M. J. L., Mensenkamp, A. R., van den Ouweland, A. M., Prins, J. B., Wagner, A., Dinjens, W. N. M., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2013-101987 · Cited by 15
Raetz, A. G., Banda, D. M., Ma, X., Xu, G., Rajavel, A. N., McKibbin, P. L., Lebrilla, C. B., & David, S. S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010497 · Cited by 15
Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells
Hollenbach, J. P., Resch, A. M., Palakodeti, D., Graveley, B. R., & Heinen, C. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021808 · Cited by 15
A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA
Komori, K., Takagi, Y., Sanada, M., Lim, T.-H., Nakatsu, Y., Tsuzuki, T., Sekiguchi, M., & Hidaka, M. (2009) · Oncogene · doi:10.1038/onc.2008.462 · Cited by 15
Different initial steps of apoptosis induced by two types of antineoplastic drugs
Takagi, Y., Hidaka, M., Sanada, M., Yoshida, H., & Sekiguchi, M. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.05.008 · Cited by 15
Beardsley, D. I., Kim, W.-J., & Brown, K. D. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.013888 · Cited by 15
Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine
Lupari, E., Ventura, I., Marcon, F., Aquilina, G., Dogliotti, E., & Fortini, P. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.03.004 · Cited by 15
Jang, E. R., Ryu, M., Park, J. E., Kim, J. H., Lee, J., & Song, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.070466 · Cited by 14
Prolonged Cell Cycle Response of HeLa Cells to Low-Level Alkylation Exposure
Schroering, A. G., Kothandapani, A., Patrick, S. M., Saravanan, K., Sharma, V. P., & Williams, K. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0899 · Cited by 14
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Izumchenko, E., Saydi, J., & Brown, K. D. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.09.004 · Cited by 13
E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor
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Narine, K. A. D., Keuling, A. M., Gombos, R. B., Tron, V. A., Andrew, S. E., & Young, L. C. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.11.010 · Cited by 13
Kadyrova, L. Y., Dahal, B. K., & Kadyrov, F. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.760561 · Cited by 13
Touny, L. H. E., Hose, C. D., Connelly, J., Harris, E. D., Monks, A. P., Dull, A. B., Wilsker, D. F., Hollingshead, M. G., Gottholm-Ahalt, M. M., Alcoser, S. Y., et al. (2021) · Oncotarget · doi:10.18632/oncotarget.28090 · Cited by 12
Chung, H., Chaudhry, J., López, C. G., & Carethers, J. M. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.11.13447 · Cited by 12
Takeishi, Y., Fujikane, R., Rikitake, M., Obayashi, Y., Sekiguchi, M., & Hidaka, M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008854 · Cited by 12
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Scherer, S. J., Avdievich, E., & Edelmann, W. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330689 · Cited by 12
Takeishi, Y., Fujikane, R., Rikitake, M., Obayashi, Y., Sekiguchi, M., & Hidaka, M. (2020) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)49915-7 · Cited by 12
Liccardo, R., Sessa, R., Trombetti, S., Rosa, M. D., Izzo, P., Grosso, M., & Duraturo, F. (2021) · Cancers · doi:10.3390/cancers13184662 · Cited by 11
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Saravanan, K., Patrick, S. M., & Williams, K. J. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.10.008 · Cited by 11
Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens
Boeckmann, L., Nickel, A., Kuschal, C., Schäfer, A., Thoms, K., Schön, M. P., Thomale, J., & Emmert, S. (2011) · Melanoma Research · doi:10.1097/cmr.0b013e328345af95 · Cited by 11
Mismatch repair deficiency does not enhance ENU mutagenesis in the zebrafish germ line
Feitsma, H., de Bruijn, E., van de Belt, J., Nijman, I. J., & Cuppen, E. P. J. G. (2008) · Mutagenesis · doi:10.1093/mutage/gen019 · Cited by 11
Nonrepair functions of DNA mismatch repair proteins: new avenues for precision oncology
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Ethanol‐induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome
Cerretelli, G., Zhou, Y. Y., Müller, M. F., Adams, D. J., & Arends, M. J. (2021) · The Journal of Pathology · doi:10.1002/path.5796 · Cited by 12
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Kontogeorgos, G., & Thodou, E. (2019) · HORMONES · doi:10.1007/s42000-019-00145-1 · Cited by 9
Embryonic Lethality after Combined Inactivation of Fancd2 and Mlh1 in Mice
van de Vrugt, H. J., Eaton, L., Newell, A. H., Al-Dhalimy, M., Liskay, R. M., Olson, S. B., & Grompe, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2452 · Cited by 9
A small interference RNA screen revealed proteasome inhibition as strategy for glioblastoma therapy.
Ng, K., Nitta, M., Hu, L., Kesari, S., Kung, A. L., D’Andrea, A. D., & Chen, C. C. (2009) · PubMed · Cited by 8
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Shimohara, C., Sawai, T., & Yagi, T. (2008) · Genes and Environment · doi:10.3123/jemsge.30.92 · Cited by 8
van Zeeland, A. A., de Groot, A. J. L., Mohn, G. R., STEEG, H. V., van Oostrom, C., van Duyn-Goedhart, A., Mullenders, L. H. F., & Jansen, J. G. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.12.011 · Cited by 8
DNA Methylation Damage: Formation, Repair and Biological Consequences
Christmann, M., Roos, W. P., & Kaina, B. (2007) · Springer eBooks · doi:10.1007/978-3-540-71414-9_7 · Cited by 7
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Fang, C., Zhang, G., Ye, S., Tian, S., Li, H., Zuo, F., Wan, J., & Cai, H. (2025) · Science Progress · doi:10.1177/00368504251345014 · Cited by 8
Li, H., Shao, J., Lu, X., Gao, Z., & Yu, Y. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.06.013 · Cited by 7
Shen, J., Chen, W., Yin, X., & Yu, Y. (2008) · Journal of Proteome Research · doi:10.1021/pr800133q · Cited by 7
Liu, C., Wang, Z., Huen, M. S. Y., Lu, L., Liu, D., & Huang, J. (2009) · Oligonucleotides · doi:10.1089/oli.2009.0191 · Cited by 7
Rikitake, M., Fujikane, R., Obayashi, Y., Oka, K., Ozaki, M., & Hidaka, M. (2020) · Genes to Cells · doi:10.1111/gtc.12748 · Cited by 7
Sun, G., Jin, S., & Baskaran, R. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.09.010 · Cited by 7
Koryllou, A., Patrinou-Georgoula, M., Troungos, C., & Pletsa, V. (2009) · APOPTOSIS · doi:10.1007/s10495-009-0379-x · Cited by 7
Personalized therapy for urothelial cancer: review of the clinical evidence
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Metadata
- Authors
- Stojic, L., Mojas, N., Cejka, P., di Pietro, M., Ferrari, S., Marra, G., & Jiricny, J.
- Affiliations
- University of Zurich (CH)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-06-01
- Volume
- 18
- Issue
- 11
- Pages
- 1331-1344
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC420358
- OpenAlex
- W2127970987
- Cited by
- 246
- References
- 61
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 8 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 17 · 2013: 14 · 2012: 14
- Type
- posted content
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- Locations
- Genes & Development (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (064650)
- National Institutes of Health
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- DNA mismatch repair, G2 checkpoint, ATR kinase, N-methyl-N'-nitro-N-nitrosoguanidine, O6-methylguanine, cell cycle arrest, ATM kinase, Chk1, γH2AX, replication protein A, DNA repair
- MeSH terms
- Checkpoint Kinase 1, Caffeine, Cell Cycle, Cell Line, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Dose-Response Relationship, Drug, Enzyme Inhibitors, Histones, Humans, Methylation, Methylnitronitrosoguanidine, Phosphorylation, Protein Kinases, Signal Transduction, G2 Phase, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Staurosporine, Base Pair Mismatch, Tumor Suppressor Proteins, Protein Kinase Inhibitors, Replication Protein A, Ataxia Telangiectasia Mutated Proteins
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