Cited by 131DNA Repair MechanismsGlioma Diagnosis and TreatmentCancer-related Molecular Pathways

DNA Damage Induced by Temozolomide Signals to both ATM and ATR: Role of the Mismatch Repair System

Caporali, Simona, Falcinelli, Sabrina, Starace, Giuseppe, Russo, Maria Teresa, Bonmassar, Enzo, Jiricny, Josef, D’Atri, Stefania·2004·Molecular Pharmacology

Integrity signals

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Crossref · 10.1016/s0026-895x(24)05630-x

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40 of 40 references verified0 citation errors · 0 not checkable

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  • In response to temozolomide, the ATR-Chk1 checkpoint is activated to arrest the cell cycle at G2/M, followed by ATM-Chk2 activation, suggesting ATR acts earlier than ATM.

    “Alternatively, in response to the DNA methylating agent temozolomide, the ATR-Chk1 checkpoint is activated to arrest cell cycle at G2/M transition. This is followed by ATM-Chk2 checkpoint activation, suggesting ATR functions earlier than ATM [143].”

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Authors
Caporali, S., Falcinelli, S., Starace, G., Russo, M. T., Bonmassar, E., Jiricny, J., & D’Atri, S.
Affiliations
University of Zurich (CH)
Corresponding author
D’Atri, Stefania
Venue
Molecular Pharmacology
Publisher
Elsevier BV
Published
2004-09
Volume
66
Issue
3
Pages
478-491
ISSN
0026-895X (ISSN-L)
OpenAlex
W4405993409
Cited by
131
References
41
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 1 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 8 · 2012: 7
FWCI
1.89
Type
journal article
Language
en
Open access
closed
Locations
Molecular Pharmacology (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
temozolomide, DNA mismatch repair, ATM kinase, ATR kinase, G2/M checkpoint, DNA damage signaling, Chk1 phosphorylation, Chk2 phosphorylation, p53 Ser15 phosphorylation, apoptosis, methylating agents, DNA repair

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