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A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation.
Open accessAbstract
Initiation of translation on poliovirus mRNA occurs by internal binding of ribosomes to a region within the 5'-noncoding portion of the mRNA. The mechanistic details and trans-acting factors involved in this event are not understood fully. We used a mobility-shift electrophoresis assay to identify a specific RNA-protein complex, which can form between an RNA fragment that contains nucleotides 559-624 of the poliovirus 5' UTR (untranslated region) and a component or components of a HeLa cell extract. Complex formation was reduced greatly in a reticulocyte lysate or a wheat-germ extract. A 52-kD polypeptide (p52) has been identified as part of the protein-RNA complex by use of an UV cross-linking assay. This polypeptide apparently is not a known translation initiation or elongation factor. The possible involvement of p52 in translation initiation of poliovirus protein synthesis is discussed.
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Cited by
An analysis of vertebrate mRNA sequences: intimations of translational control.
Kozak, M. (1991) · The Journal of cell biology · doi:10.1083/jcb.115.4.887 · Cited by 1,635
Wimmer, E., Hellen, C. U. T., & Cao, X. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.002033 · Cited by 554
Vagner, S., Gensac, M.-C., Maret, A., Bayard, F., Amalric, F., Prats, H., & Prats, A.-C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.1.35 · Cited by 334
Regulation of eukaryotic protein synthesis by initiation factors.
Rhoads, R. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53649-8 · Cited by 297
Pilipenko, E. V., Gmyl, A. P., Maslova, S. V., Svitkin, Y. V., Sinyakov, A. N., & Agol, V. I. (1992) · Cell · doi:10.1016/0092-8674(92)90211-t · Cited by 276
Metadata
- Authors
- Meerovitch, K., Pelletier, J., & Sonenberg, N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1989-07
- Volume
- 3
- Issue
- 7
- Pages
- 1026-1034
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2143656082
- Cited by
- 268
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Meerovitch, K., Pelletier, J., & Sonenberg, N. (1989). A cellular protein that binds to the 5'-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes & Development. https://doi.org/10.1101/gad.3.7.1026
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