The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.
Open accessAbstract
We have cloned and characterized the mouse homolog of the human trk proto-oncogene, a member of the protein tyrosine kinase (TK) receptor gene family. Here, we present the first report of a trk-encoded mRNA species in vivo. In situ hybridization analysis in the mouse embryo reveals a striking temporal and spatial regulation of trk transcription, with expression confined to the sensory cranial (trigeminal, superior, jugular) and dorsal root ganglia (DRG) of neural crest origin. Recent reports have shown that TK receptors can play regulatory roles in embryonic development. Thus, the developmental mutations W in mouse and torso and sevenless in Drosophila represent genes that code for defective TK receptors. Our data show that trk, a gene associated with malignancy in humans, is a specific marker for a set of neural crest-derived sensory neurons, and are consistent with the hypothesis that this proto-oncogene may have an important role in the development or phenotype of the neurons where it is expressed.
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Citations
Cites
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
Geissler, E. N., Ryan, M. A., & Housman, D. E. (1988) · Cell · doi:10.1016/0092-8674(88)90020-7 · Cited by 1,287
Cited by
Grasping objects: the cortical mechanisms of visuomotor transformation
Jeannerod, M., Arbib, M. A., Rizzolatti, G., & Sakata, H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93921-j · Cited by 1,399
The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor
Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science · doi:10.1126/science.1850549 · Cited by 1,379
Self-citationThe Trk family of neurotrophin receptors
Barbacid, M. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251107 · Cited by 1,281
Self-citationHempstead, B. L., Martin-Zanca, D., Kaplan, D. R., Parada, L. F., & Chao, M. V. (1991) · Nature · doi:10.1038/350678a0 · Cited by 1,229
Self-citationSevere sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene
Smeyne, R. J., Klein, R., Schnapp, A., Long, L. K., Bryant, S., Lewin, A., Lira, S. A., & Barbacid, M. (1994) · Nature · doi:10.1038/368246a0 · Cited by 981
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Metadata
- Authors
- Martin-Zanca, D., Barbacid, M., & Parada, L. F.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-05
- Volume
- 4
- Issue
- 5
- Pages
- 683-694
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2139685495
- Cited by
- 343
- References
- 1
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. https://app.cochat.ai/papers/10.1101/gad.4.5.683
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- Martin-Zanca, D., Barbacid, M., & Parada, L. F. (1990). Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes & Development. https://doi.org/10.1101/gad.4.5.683
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