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Cited by 115T-cell and Retrovirus StudiesRNA Research and SplicingHIV Research and Treatment

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Structure-function analyses of the HTLV-I Rex and HIV-1 Rev RNA response elements: insights into the mechanism of Rex and Rev action

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Ahmed, Y F, Hanly, S M, Malim, M H, Cullen, B R, Greene, W C·1990·Genes & Development
DOI 10.1101/gad.4.6.1014
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Abstract

The ability of the Rex protein of the type I human T-cell leukemia virus (HTLV-I) to regulate expression of the retroviral gag and env structural genes post-transcriptionally is critically dependent on the presence of a Rex response element (RexRE). This cis-regulatory sequence is located within the retroviral 3' long terminal repeat and coincides with a predicted, highly stable RNA stem-loop structure. Rex action requires both the overall secondary structure intrinsic to the RexRE and specific sequences from one small subregion of this large structure. This small subregion likely forms a protein-binding site for Rex or a cellular RNA-binding factor. Whereas Rex can functionally replace the Rev protein of the type 1 human immunodeficiency virus (HIV-1) through its interaction with the analogous Rev response element (RevRE), distinct subregions of this HIV-1 RNA element mediate the responses to Rex and Rev. Strikingly, Rex acts as a dominant repressor of Rev action, following the deletion of the Rex responsive subregion of the RevRE. Similarly, Rev inhibits Rex function in a dominant manner when the Rev responsive subregion of the RevRE is deleted. Together, these findings suggest that Rex and Rev not only interact with their respective RNA response elements but also may either form mixed inactive multimers or interact with a common cellular factor(s). If binding of a common host protein is involved, this factor likely plays a central role either in spliceosome assembly or nuclear RNA transport.

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Metadata

Authors
Ahmed, Y. F., Hanly, S. M., Malim, M. H., Cullen, B. R., & Greene, W. C.
Affiliations
Howard Hughes Medical Institute (US)
ORCID
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
1990-06
Volume
4
Issue
6
Pages
1014-1022
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.4.6.1014
OpenAlex
W2138851210
Cited by
115
References
41
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2014: 5 · 2013: 2 · 2012: 5
Type
posted content
Language
en
Open access
Locations
  • Genes & Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
HIV-1 Rev protein, Rev response element, long terminal repeat, post-transcriptional regulation, RNA stem-loop structure, cis-regulatory elements, RNA-protein interactions, spliceosome assembly
MeSH terms
Animals, Haplorhini, Base Sequence, Cell Line, Molecular Sequence Data, Nucleic Acid Conformation, Precipitin Tests, Regulatory Sequences, Nucleic Acid, Repressor Proteins, RNA Splicing, RNA, Viral, Structure-Activity Relationship, Human T-lymphotropic virus 1, Trans-Activators, Gene Products, rev, Genes, gag, Genes, env, Gene Expression Regulation, Viral

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