The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway
Open accessAbstract
In the fatal degenerative Duchenne muscular dystrophy (DMD), skeletal muscle is progressively replaced by fibrotic tissue. Here, we show that fibrinogen accumulates in dystrophic muscles of DMD patients and mdx mice. Genetic loss or pharmacological depletion of fibrinogen in these mice reduced fibrosis and dystrophy progression. Our results demonstrate that fibrinogen–Mac-1 receptor binding, through induction of IL-1β, drives the synthesis of transforming growth factor-β (TGFβ) by mdx macrophages, which in turn induces collagen production in mdx fibroblasts. Fibrinogen-produced TGFβ further amplifies collagen accumulation through activation of profibrotic alternatively activated macrophages. Fibrinogen, by engaging its αvβ3 receptor on fibroblasts, also directly promotes collagen synthesis. These data unveil a profibrotic role of fibrinogen deposition in muscle dystrophy.
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Cites
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
Regulation of immune responses by L-arginine metabolism
Bronte, V., & Zanovello, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1668 · Cited by 1,775
Fibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice
Wehling, M., Spencer, M. J., & Tidball, J. G. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105110 · Cited by 530
Flick, M. J., Du, X., Witte, D. P., Jiroušková, M., Soloviev, D. A., Busuttil, S. J., Plow, E. F., & Degen, J. L. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20741 · Cited by 450
Self-citation
Cited by
Genetic effects on gene expression across human tissues
GTEx Consortium (2017) · Nature · doi:10.1038/nature24277 · Cited by 4,036
Macrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384
Aberrant repair and fibrosis development in skeletal muscle
Mann, C. J., Perdiguero, E., Kharraz, Y., Aguilar, S., Pessina, P., Serrano, A. L., & Muñoz-Cánoves, P. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-21 · Cited by 853
“Fibrin(ogen) deposits may serve as important triggers for the inflammatory responses, because of their capacity to bind to the integrin receptor Mac-1 on classically activated M1 macrophages [27] (see above).”
BackgroundInfluentialLemos, D. R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S. T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S. A., & Rossi, F. M. V. (2015) · Nature Medicine · doi:10.1038/nm.3869 · Cited by 740
Macrophages in inflammation, repair and regeneration
Oishi, Y., & Manabe, I. (2018) · International Immunology · doi:10.1093/intimm/dxy054 · Cited by 734
Metadata
- Authors
- Vidal, B., Serrano, A. L., Tjwa, M., Suelves, M., Ardite, E., De Mori, R., Baeza-Raja, B., Martínez de Lagrán, M., Lafuste, P., Ruiz-Bonilla, V., Jardí, M., Gherardi, R., Christov, C., Dierssen, M., Carmeliet, P., Degen, J. L., Dewerchin, M., & Muñoz-Cánoves, P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2008-07-01
- Volume
- 22
- Issue
- 13
- Pages
- 1747-1752
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2150697205
- Cited by
- 257
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Vidal, B., Serrano, A. L., Tjwa, M., Suelves, M., Ardite, E., De Mori, R., Baeza-Raja, B., Martínez de Lagrán, M., Lafuste, P., Ruiz-Bonilla, V., Jardí, M., Gherardi, R., Christov, C., Dierssen, M., Carmeliet, P., Degen, J. L., Dewerchin, M., & Muñoz-Cánoves, P. (2008). Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway. Genes & Development. https://doi.org/10.1101/gad.465908
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
