Cited by 2,384Immune cells in cancerWound Healing and TreatmentsCardiac Fibrosis and Remodeling

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, Alberto, Biswas, Subhra K, Galdiero, Maria Rosaria, Sica, Antonio, Locati, Massimo·2013·The Journal of Pathology

Abstract

Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2 ‐like activation mode. Macrophages are credited with an essential role in remodelling during ontogenesis. In extraembryonic life, under homeostatic conditions, the macrophage trophic and remodelling functions are recapitulated in tissues such as bone, mammary gland, decidua and placenta. In pathology, macrophages are key components of tissue repair and remodelling that occur during wound healing, allergy, parasite infection and cancer. Interaction with cells bearing stem or progenitor cell properties is likely an important component of the role of macrophages in repair and remodelling. These properties of cells of the monocyte–macrophage lineage may represent a tool and a target for therapeutic exploitation.

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Registry

Crossref · 10.1002/path.4133

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144 of 144 references verified0 citation errors · 0 not checkable

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  • Physical properties (substrate stiffness, topography, pore size, size of wear debris), chemical properties (surface chemistry, ligand presentation, release of growth factors), and temporal properties (degradation rates) all influence cell behavior.

    “Physical properties such as substrate stiffness, topography, pore size and size of wear debris; chemical properties such as surface chemistry, ligand presentation and release of growth factors; and temporal properties, such as degradation rates, all influence the behavior of cells [8,9].”
  • A major event at the switch is a change in macrophage phenotype from inflammatory M1 to anti-inflammatory M2.

    “One of the major events at this time is a change in the phenotype of macrophages from an inflammatory and microbicidal phenotype, grouped as M1 macrophages, secreting IL-1, TNFα, IL-6, IL-12, MMPs, and other cytokines, to an anti-inflammatory, regulatory, and reparative phenotype, classed and grouped as M2, producing arginase, TGFβ, CCL18, PGE2, and IL-10 (Fig. 4).”

    From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [94]

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Authors
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M.
Affiliations
  • University of Milan (IT)
  • Agency for Science, Technology and Research (SG)
  • University of Naples Federico II (IT)
  • Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
Corresponding author
Mantovani, Alberto
Venue
The Journal of Pathology
Publisher
Wiley
Published
2012-11-29
Volume
229
Issue
2
Pages
176-185
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
OpenAlex
W1797422316
Cited by
2,384
References
144
Citations by year
2026: 126 · 2025: 137 · 2024: 189 · 2023: 192 · 2022: 244 · 2021: 223 · 2020: 203 · 2019: 196 · 2018: 172 · 2017: 184 · 2016: 165 · 2015: 154 · 2014: 124 · 2013: 72 · 2012: 2
FWCI
10.39
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
macrophage plasticity, macrophage polarization, M2 macrophages, tissue repair, tissue remodeling, inflammation resolution, wound healing, monocyte/macrophage lineage, ontogeny, placenta, decidua, mammary gland, bone remodeling, allergy, parasitic infection, cancer, therapeutic target
MeSH terms
Animals, Cell Differentiation, Homeostasis, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, Phenotype, Stem Cells, Wound Healing, Inflammation Mediators

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