The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.
Open accessAbstract
By analysis of cDNA clones that cross-hybridized with a portion of the cDNA encoding the recently described rat protein hepatocyte nuclear factor 3 alpha (HNF-3 alpha, previously called HNF-3A), we now describe two additional members, HNF-3 beta and HNF-3 gamma, of this gene family. A 110-amino-acid region in the DNA-binding domain of this family is not only very highly conserved in rodents (HNF-3 alpha, -3 beta, and -3 gamma are identical in 93 of 110 amino acids in this region) but also in Drosophila where the homeotic gene fork head has 88 of the 93 residues that are identical in the three rat genes. The HNF-3 family in rodents is expressed in cells that derive from the lining of the primitive gut; some of the embryonic Drosophila cells in which fork head is expressed also give rise to gut and salivary glands. Thus, it appears that this gene family, the DNA-binding portion of which is unlike that of any previously recognized DNA-binding proteins, may contribute to differentiation of cells in internal organs in both vertebrates and invertebrates.
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Cites
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, K., & Green, M. R. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7035 · Cited by 6,324
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Murre, C., McCaw, P. S., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,635
Vectors for selective expression of cloned DNAs by T7 RNA polymerase
Rosenberg, A. H., Lade, B. N., Dao-shan, C., Lin, S.-W., Dunn, J. J., & Studier, F. W. (1987) · Gene · doi:10.1016/0378-1119(87)90165-x · Cited by 1,443
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G., & Chasin, L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1373 · Cited by 1,279
Sladek, F. M., Zhong, W. M., Lai, E., & Darnell, J. E. (1990) · Genes & Development · doi:10.1101/gad.4.12b.2353 · Cited by 1,027
Self-citationGraham, A., Papalopulu, N., & Krumlauf, R. (1989) · Cell · doi:10.1016/0092-8674(89)90912-4 · Cited by 1,024
The role of the leucine zipper in the fos–jun interaction
Kouzarides, T., & Ziff, E. (1988) · Nature · doi:10.1038/336646a0 · Cited by 808
Weigel, D., Jürgens, G., Küttner, F., Seifert, E., & Jäckle, H. (1989) · Cell · doi:10.1016/0092-8674(89)90133-5 · Cited by 782
Cited by
Homeobox genes and axial patterning
McGinnis, W., & Krumlauf, R. (1992) · Cell · doi:10.1016/0092-8674(92)90471-n · Cited by 2,674
Compilation of vertebrate-encoded transcription factors
Faisst, S., & Meyer, S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.1.3 · Cited by 914
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma
Galili, N., Davis, R. J., Fredericks, W. J., Mukhopadhyay, S., Rauscher, F. J., Emanuel, B. S., Rovera, G., & Barr, F. G. (1993) · Nature Genetics · doi:10.1038/ng1193-230 · Cited by 892
Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90514-2 · Cited by 854
Sasaki, H., & Hogan, B. L. M. (1993) · Development · doi:10.1242/dev.118.1.47 · Cited by 667
Metadata
- Authors
- Lai, E., Prezioso, V. R., Tao, W. F., Chen, W. S., & Darnell, J. E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1991-03
- Volume
- 5
- Issue
- 3
- Pages
- 416-427
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1990283480
- Cited by
- 502
- References
- 34
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. https://app.cochat.ai/papers/10.1101/gad.5.3.416
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- Lai, E., Prezioso, V. R., Tao, W. F., Chen, W. S., & Darnell, J. E. (1991). Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes & Development. https://doi.org/10.1101/gad.5.3.416
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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