The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mice develop normally without tenascin.
Open accessAbstract
Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena. To directly assess the function of tenascin in vivo, we generated mutant mice in which the tenascin gene was nully disrupted by replacing it with the lacZ gene. In mutant mice, lacZ was expressed in place of tenascin, and no tenascin product was detected. Homozygous mutant mice were, however, obtained in accordance with Mendelian laws, and both females and males produced offspring normally. No anatomical or histological abnormalities were detected in any tissues, and no major changes were observed in distribution of fibronectin, laminin, collagen, and proteoglycan. The existence of these mutant mice, lacking tenascin yet phenotypically normal, casts doubt on the theory that tenascin plays and essential role in normal development.
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Cites
Induction of tenascin in healing wounds
Mackie, E. J., Halfter, W., & Liverani, D. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.6.2757 · Cited by 555
Two contrary functions of tenascin: Dissection of the active sites by recombinant tenascin fragments
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Cited by
Degeneracy and complexity in biological systems
Edelman, G. M., & Gally, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231499798 · Cited by 1,493
Regulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,208
Role of duplicate genes in genetic robustness against null mutations
Gu, Z., Steinmetz, L. M., Gu, X., Scharfe, C., Davis, R. W., & Li, W.-H. (2003) · Nature · doi:10.1038/nature01198 · Cited by 889
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
Oskarsson, T., Acharyya, S., Zhang, X. H.-F., Vanharanta, S., Tavazoie, S. F., Morris, P. G., Downey, R. J., Manova-Todorova, K., Brogi, E., & Massagué, J. (2011) · Nature Medicine · doi:10.1038/nm.2379 · Cited by 869
Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1.
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Metadata
- Authors
- Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T., & Aizawa, S.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1992-10
- Volume
- 6
- Issue
- 10
- Pages
- 1821-1831
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2103511872
- Cited by
- 582
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T., & Aizawa, S. (1992). Mice develop normally without tenascin. Genes & Development. https://doi.org/10.1101/gad.6.10.1821
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