The DOI matches its Crossref record.
Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae.
Open accessAbstract
The spatially restricted activities of achaete (ac) and scute (sc) are thought to define proneural clusters of potential sensory organ precursor cells in the imaginal discs of Drosophila. These genes encode transcriptional regulators of the basic helix-loop-helix (bHLH) class. We have found that direct, positive transcriptional autoregulation by the ac protein and cross-regulation by sc are essential for high-level expression of the ac promoter in the proneural cluster pattern and that autoactivation is important for the bristle-promoting function of the ac gene. These auto- and cross-regulatory activities are antagonized in a dose-dependent manner by the inhibitory HLH protein encoded by the extramacrochaetae (emc) gene. We have found that emc is expressed in the wing imaginal disc in a pattern strongly complementary to that of the proneural clusters. Our results indicate that emc plays an essential early role in defining territories of bristle-forming potential.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Hinz, U., Giebel, B., & Campos-Ortega, J. (1994) · Cell · doi:10.1016/0092-8674(94)90174-0 · Cited by 301
Autoregulation and multiple enhancers control Math1 expression in the developing nervous system
Helms, A. W., Abney, A. L., Ben-Arie, N., Zoghbi, H. Y., & Johnson, J. E. (2000) · Development · doi:10.1242/dev.127.6.1185 · Cited by 289
Presenilin-1 regulates neuronal differentiation during neurogenesis
Handler, M., Yang, X., & Shent, J. (2000) · Development · doi:10.1242/dev.127.12.2593 · Cited by 225
Genetic mechanisms of early neurogenesis inDrosophila melanogaster
Campos-Ortega, J. A. (1995) · Molecular Neurobiology · doi:10.1007/bf02740668 · Cited by 137
Metadata
- Authors
- Van Doren, M., Powell, P. A., Pasternak, D., Singson, A., & Posakony, J. W.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1992-12-01
- Volume
- 6
- Issue
- 12b
- Pages
- 2592-2605
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2003927747
- Cited by
- 172
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. https://app.cochat.ai/papers/10.1101/gad.6.12b.2592
- The paper
- Van Doren, M., Powell, P. A., Pasternak, D., Singson, A., & Posakony, J. W. (1992). Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes & Development. https://doi.org/10.1101/gad.6.12b.2592
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
