The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes.
Open accessAbstract
Previous studies suggest that the CCAAT/enhancer-binding protein (C/EBP) functions in the coordinate expression of adipocyte genes during differentiation of 3T3-L1 preadipocytes. We sought to block expression of C/EBP selectively using a bovine papilloma virus (BPV) vector to direct transcription of a approximately 0.4-kb segment of C/EBP cDNA (in antisense orientation) containing translated sequence 5' to that encoding the basic and leucine zipper regions of the protein. Vector-directed expression of antisense C/EBP RNA in 3T3-L1 preadipocytes inhibited expression of C/EBP mRNA and protein, as well as several adipose-specific mRNAs, and also prevented cytoplasmic triglyceride accumulation. Rescue of the "adipocyte phenotype" was accomplished by transfection of cells expressing antisense RNA with a modified BPV vector that directs transcription of the complementary sense C/EBP RNA.
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Citations
Cites
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.
Cao, Z., Umek, R. M., & McKnight, S. L. (1991) · Genes & Development · doi:10.1101/gad.5.9.1538 · Cited by 1,663
CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch
Umek, R. M., Friedman, A. D., & McKnight, S. L. (1991) · Science · doi:10.1126/science.1987644 · Cited by 712
Birkenmeier, E. H., Gwynn, B., Howard, S., Jerry, J., Gordon, J. I., Landschulz, W. H., & McKnight, S. L. (1989) · Genes & Development · doi:10.1101/gad.3.8.1146 · Cited by 613
Cited by
Understanding Adipocyte Differentiation
GREGOIRE, F. M., SMAS, C. M., & SUL, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,376
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
Alberini, C. M., Ghirardl, M., Metz, R., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90386-7 · Cited by 523
Scott, L., Civin, C., Rorth, P., & Friedman, A. (1992) · Blood · doi:10.1182/blood.v80.7.1725.1725 · Cited by 409
Mandrup, S., & Lane, M. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5367 · Cited by 404
Self-citationCytoplasmic fatty acid-binding proteins: Their structure and genes
Veerkamp, J. H., & Maatman, R. G. H. J. (1995) · Progress in Lipid Research · doi:10.1016/0163-7827(94)00005-7 · Cited by 355
Metadata
- Authors
- Lin, F. T., & Lane, M. D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1992-04
- Volume
- 6
- Issue
- 4
- Pages
- 533-544
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2101127398
- Cited by
- 330
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Lin, F. T., & Lane, M. D. (1992). Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. Genes & Development. https://doi.org/10.1101/gad.6.4.533
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