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Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene.
Open accessAbstract
Numerous lines of study have suggested that the Hox genes, encoding putative transcription factors, are key genes in the establishment of the body plan of the mammalian embryo. To examine the role of Hoxa-5 (Hox1.3) gene during development, we have used targeted mutagenesis in embryonic stem cells to produce a strain of mice carrying a disrupted Hoxa-5 allele. The viability of homozygous mutant mice is markedly reduced, with 50% of the mutant animals dying at birth or shortly thereafter. Analysis of the skeleton of Hoxa-5 mutants reveals a number of homeotic transformations restricted to the cervical and thoracic regions. Of these, one of the most frequent morphological abnormalities is the posterior transformation of the seventh cervical vertebra into the likeness of a thoracic vertebra complete with a pair of ribs. These results demonstrate that the Hoxa-5 gene has an important role in the establishment of the skeleton during development and contributes to the process whereby the axial structures are determined.
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Citations
Cited by
Duboule, D. (1994) · Development · doi:10.1242/dev.1994.supplement.135 · Cited by 631
PARALOGOUS HOX GENES: Function and Regulation
Maconochie, M., Nonchev, S., Morrison, A., & Krumlauf, R. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.529 · Cited by 220
Butcher, D. T., Cytrynbaum, C., Turinsky, A. L., Siu, M. T., Inbar-Feigenberg, M., Mendoza-Londono, R., Chitayat, D., Walker, S., Machado, J., Caluseriu, O., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.04.004 · Cited by 200
Chapter 9 Hox Genes and Vertebrate Axial Pattern
Wellik, D. M. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88009-5 · Cited by 203
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis.
Sylva, M., Li, V. S. W., Buffing, A. A. A., van Es, J. H., van den Born, M., van der Velden, S., Gunst, Q., Koolstra, J. H., Moorman, A. F. M., Clevers, H., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022616 · Cited by 97
Metadata
- Authors
- Jeannotte, L., Lemieux, M., Charron, J., Poirier, F., & Robertson, E. J.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-11
- Volume
- 7
- Issue
- 11
- Pages
- 2085-2096
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2049469517
- Cited by
- 182
- References
- 0
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Jeannotte, L., Lemieux, M., Charron, J., Poirier, F., & Robertson, E. J. (1993). Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene. Genes & Development. https://doi.org/10.1101/gad.7.11.2085
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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