Cited by 308Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancerGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

Open access

Francois, V, Solloway, M, O'Neill, J W, Emery, J, Bier, E·1994·Genes & Development

DOI 10.1101/gad.8.21.2602

Open this paper in CoChat — free account Open PDF

Abstract

Pattern formation in the dorsal region of the Drosophila embryo depends on the activity of a small group of zygotically acting genes. dpp, a key gene in this group, encodes a TGF-beta-like product (Dpp) that has been proposed to function as a morphogen with peak levels of Dpp-specifying amnioserosa, the dorsal-most cell type, and lower Dpp levels specifying dorsal ectoderm. The short gastrulation gene also contributes to patterning the dorsal region, but unlike the other genes involved in this process, sog activity is only required in ventral cells. Genetic evidence indicates that sog functions to antagonize dpp activity. In this report we present further phenotypic characterization of sog mutant embryos in dorsal and lateral regions and describe the cloning of the sog locus. sog is expressed in a broad lateral stripe of cells that abuts the dorsal territory of dpp-expressing cells. sog is predicted to encode a protein with an internal signal sequence and a large extracellular domain containing four repeats of a novel motif defined by the spacing of 10 cysteine residues that is distantly related to domains present in thrombospondin and procollagen. We propose that one or more of these cysteine repeats can be liberated by proteolytic cleavage of the primary Sog protein. These putative soluble Sog peptides may then diffuse into the dorsal region to antagonize the activity of Dpp, leading to the subdivision of the dorsal territory into amnioserosa and dorsal ectoderm.

Integrity signals

Registry

Crossref · 10.1101/gad.8.21.2602

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A simple method for displaying the hydropathic character of a protein
Kyte, J., & Doolittle, R. F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90515-0 · Cited by 22,927
The Genome of Drosophila Melanogaster
Lindsley, D. L., & Zimm, G. G. (1992) · Cited by 3,098
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint
Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
N�sslein-Volhard, C., Wieschaus, E. F., & Kluding, H. (1984) · Development Genes and Evolution · doi:10.1007/bf00848156 · Cited by 1,552
Comparison of the consensus sequence flanking translational start sites inDrosophilaand vertebrates
Cavener, D. R. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.4.1353 · Cited by 937
Activin-Binding Protein from Rat Ovary Is Follistatin
Nakamura, T., Takio, K., Eto, Y., Shibai, H., Titani, K., & Sugino, H. (1990) · Science · doi:10.1126/science.2106159 · Cited by 883
Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.
Bradham, D. M., Igarashi, A., Potter, R. L., & Grotendorst, G. R. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.6.1285 · Cited by 878
Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog protein
Basler, K., & Struhl, G. (1994) · Nature · doi:10.1038/368208a0 · Cited by 834
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity
Hemmati‐Brivanlou, A., Kelly, O., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90320-4 · Cited by 761
A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family
Padgett, R. W., Johnston, D. S., & Gelbart, W. M. (1987) · Nature · doi:10.1038/325081a0 · Cited by 758
MEMBRANE-ANCHORED GROWTH FACTORS
Massagué, J., & Pandiella, A. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.002503 · Cited by 665
A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
Roth, S., Stein, D., & Nüsslein‐Volhard, C. (1989) · Cell · doi:10.1016/0092-8674(89)90774-5 · Cited by 652
Expression cloning and characterization of the TGF-β type III receptor
Wang, X., Lin, H. Y.-F., Eaton, E. N., Downward, J., Lodish, H. F., & Weinberg, R. A. (1991) · Cell · doi:10.1016/0092-8674(91)90074-9 · Cited by 635
Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
Tabata, T., & Kornberg, T. B. (1994) · Cell · doi:10.1016/0092-8674(94)90175-9 · Cited by 616
twist and snail as positive and negative regulators during Drosophila mesoderm development.Preprint
Leptin, M. (1991) · Genes & Development · doi:10.1101/gad.5.9.1568 · Cited by 571
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity
Tolsma, S. S., Volpert, O. V., Good, D., Frazier, W., Polverini, P., & Bouck, N. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.2.497 · Cited by 565
A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction
Hunter, D. D., Shah, V., Merlie, J., & Sanes, J. (1989) · Nature · doi:10.1038/338229a0 · Cited by 559
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
Wieschaus, E. F., N�sslein-Volhard, C., & J�rgens, G. (1984) · Development Genes and Evolution · doi:10.1007/bf00848158 · Cited by 556
decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo
Ferguson, E. L., & Anderson, K. V. (1992) · Cell · doi:10.1016/0092-8674(92)90514-d · Cited by 492
Inhibition of activin receptor signaling promotes neuralization in Xenopus
Hemmati‐Brivanlou, A., & Melton, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90319-0 · Cited by 491
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
Rushlow, C. A., Han, K., Manley, J. L., & Levine, M. (1989) · Cell · doi:10.1016/0092-8674(89)90772-1 · Cited by 476
Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22
Hultmark, D. (1986) · Cell · doi:10.1016/0092-8674(86)90464-2 · Cited by 455
Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.
Ueno, N., LING, N. C., Ying, S. Y., Esch, F. S., Shimasaki, S., & Guillemin, R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8282 · Cited by 445
Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function
Steward, R. (1989) · Cell · doi:10.1016/0092-8674(89)90773-3 · Cited by 438
An Update on the Roles of Inhibin, Activin, and Follistatin as Local Regulators of Folliculogenesis1
Findlay, J. K. (1993) · Biology of Reproduction · doi:10.1095/biolreprod48.1.15 · Cited by 424
rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.
Bier, E., Jan, L. Y., & Jan, Y. N. (1990) · Genes & Development · doi:10.1101/gad.4.2.190 · Cited by 393
Self-citation
Transforming growth factor β type 1 binds to collagen IV of basement membrane matrix: Implications for development
Paralkar, V. M., Vukičević, S., & Reddi, A. H. (1991) · Developmental Biology · doi:10.1016/0012-1606(91)90081-d · Cited by 352
The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin
Robertson, D. M., Klein, R., de Vos, F. L., McLachlan, R. I., Wettenhall, R. E. H., Hearn, M. T. W., Burger, H., & de Kretser, D. M. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)90430-x · Cited by 345
Mullerian Inhibiting Substance: A Gonadal Hormone with Multiple Functions*
Lee, M., & Donahoe, P. K. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-2-152 · Cited by 333
The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.Preprint
Ip, Y. T., Park, R., Kosman, D., Bier, E., & Levine, M. (1992) · Genes & Development · doi:10.1101/gad.6.9.1728 · Cited by 324
Self-citation
Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGFβ family member
Basler, K., Edlund, H., Jessell, T. M., & Yamada, T. (1993) · Cell · doi:10.1016/0092-8674(93)90249-p · Cited by 319
Identification of a phorbol ester-repressible v-src-inducible gene.
Simmons, D. L., Levy, D. B., Yannoni, Y. M., & Erikson, R. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1178 · Cited by 316
Characterization and relationship of dpp receptors encoded by the saxophone and thick veins genes in Drosophila
Brummel, T., Twombly, V. J., Marqués, G., Wrana, J. L., Newfeld, S. J., Attisano, L., Massagué, J., O’Connor, M. B., & Gelbart, W. M. (1994) · Cell · doi:10.1016/0092-8674(94)90295-x · Cited by 313
The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1
Shimell, M., Ferguson, E. L., Childs, S. R., & O’Connor, M. B. (1991) · Cell · doi:10.1016/0092-8674(91)90522-z · Cited by 296
What do BMPs do in mammals? Clues from the mouse short-ear mutation
Kingsley, D. M. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90014-0 · Cited by 293
An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo
Wharton, K. A., Ray, R. P., & Gelbart, W. M. (1993) · Development · doi:10.1242/dev.117.2.807 · Cited by 292
The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.Preprint
Irish, V. F., & Gelbart, W. M. (1987) · Genes & Development · doi:10.1101/gad.1.8.868 · Cited by 287
Human BMP sequences can confer normal dorsal-ventral patterning in the Drosophila embryo.
Padgett, R. W., Wozney, J. M., & Gelbart, W. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2905 · Cited by 285
Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic
Anthamatten, D., Affolter, M., & Basler, K. (1994) · Cell · doi:10.1016/0092-8674(94)90293-3 · Cited by 275
Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos
Reuter, R., Panganiban, G. E. F., Hoffmann, F. M., & Scott, M. P. (1990) · Development · doi:10.1242/dev.110.4.1031 · Cited by 263
Transforming growth factor-beta complexes with thrombospondin.
Murphy-Ullrich, J. E., Schultz‐Cherry, S., & Höök, M. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.2.181 · Cited by 258
Full‐length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit.
Verweij, C. L., Diergaarde, P. J., Hart, M. H. L., & Pannekoek, H. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04435.x · Cited by 258
Identification of two bone morphogenetic protein type I receptors in Drosophila and evidence that Brk25D is a decapentaplegic receptor
Penton, A. L., Chen, Y., Staehling‐Hampton, K., Wrana, J. L., Attisano, L., Szidonya, J., Cassill, J. A., Massagué, J., & Hoffmann, F. M. (1994) · Cell · doi:10.1016/0092-8674(94)90294-1 · Cited by 254
Decapentaplegic transcripts are localized along the dorsal‐ventral axis of the Drosophila embryo.
Johnston, D. S., & Gelbart, W. M. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02574.x · Cited by 247
The control of cell fate along the dorsal-ventral axis of the Drosophila embryo
Ray, R. P., Arora, K., Nüsslein‐Volhard, C., & Gelbart, W. M. (1991) · Development · doi:10.1242/dev.113.1.35 · Cited by 246
A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis
Panganiban, G. E. F., Reuter, R., Scott, M. P., & Hoffmann, F. M. (1990) · Development · doi:10.1242/dev.110.4.1041 · Cited by 245
Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo
Kosman, D., Ip, Y. T., Levine, M., & Arora, K. (1991) · Science · doi:10.1126/science.1925551 · Cited by 243
Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.
Sampath, T. K., Rashka, K. E., Doctor, J. S., Tucker, R. F., & Hoffmann, F. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.6004 · Cited by 229
Localized enhancement and repression of the activity of the TGF-P family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo
Ferguson, E. L., & Anderson, K. V. (1992) · Development · doi:10.1242/dev.114.3.583 · Cited by 228
Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis.
Kulozik, M., Hogg, A., Lankat–Buttgereit, B., & Krieg, T. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114793 · Cited by 213
Human proα1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons
Chu, M., de Wet, W., Bernard, M. P., Ding, J.-F., Morabito, M. A., Myers, J. C., Williams, C. J., & Ramirez, F. (1984) · Nature · doi:10.1038/310337a0 · Cited by 207
Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.
Murata, M., Eto, Y., Shibai, H., Sakai, M., & Muramatsu, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2434 · Cited by 199
The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo.Preprint
Arora, K., Levine, M., & O’Connor, M. B. (1994) · Genes & Development · doi:10.1101/gad.8.21.2588 · Cited by 198
Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis
Capovilla, M., Brandt, M. L., & Botas, J. (1994) · Cell · doi:10.1016/0092-8674(94)90111-2 · Cited by 178
Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes.
O’Neill, J., & Bier, E. (1994) · PubMed · Cited by 156
Self-citation
Topological similarities in TGF-β2, PDGF-BB and NGF define a superfamily of polypeptide growth factors
Murray‐Rust, J., McDonald, N. Q., Blundell, T. L., Hosang, M., Oefner, C., Winkler, F. K., & Bradshaw, R. A. (1993) · Structure · doi:10.1016/0969-2126(93)90029-g · Cited by 155
Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.
Nakatsukasa, H., Evarts, R. P., Hsia, C. C., & Thorgeirsson, S. S. (1990) · PubMed · Cited by 143
Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila
Rushlow, C. A., Frasch, M., Doyle, H. J., & Levine, M. (1987) · Nature · doi:10.1038/330583a0 · Cited by 141
Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.Preprint
Mason, E. D., Konrad, K. D., Webb, C. D., & Marsh, J. (1994) · Genes & Development · doi:10.1101/gad.8.13.1489 · Cited by 135
The Drosophila saxophone Gene: a Serine-Threonine Kinase Receptor of the TGF-β Superfamily
Xie, T., Finelli, A. L., & Padgett, R. W. (1994) · Science · doi:10.1126/science.8134837 · Cited by 127
Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes
Arora, K., & Nüsslein‐Volhard, C. (1992) · Development · doi:10.1242/dev.114.4.1003 · Cited by 124
Identification of a Gene Family Regulated by Transforming Growth Factor-β
Brunner, A., Chinn, J., Neubauer, M., & Purchio, A. F. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.293 · Cited by 124
A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome
BORNSTEIN, P. K., O’Rourke, K. M., Wikstrom, K. I., Wolf, F. W., Katz, R. W., Li, P., & Dixit, V. M. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98764-8 · Cited by 120
Activin/EDF as an inhibitor of neural differentiation
Hashimot, M., Kondo, S., Sakurai, T., Etoh, Y., Shibai, H., & Muramatsu, M. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81040-x · Cited by 117
Cross regulation of decapentaplegic and Ultrabithorax transcription in the embryonic visceral mesoderm of Drosophila
Hursh, D. A., Padgett, R. W., & Gelbart, W. M. (1993) · Development · doi:10.1242/dev.117.4.1211 · Cited by 115
Regulation of the alpha 1(I) collagen promoter via a transforming growth factor-beta activation element
Ritzenthaler, J. D., Goldstein, R. H., Fine, A., & Smith, B. D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38694-6 · Cited by 107
Transcripts encoded by a homoeo box gene are restricted to dorsal tissues of Drosophila embryos
Doyle, H. J., Harding, K. W., Hoey, T. C., & Levine, M. (1986) · Nature · doi:10.1038/323076a0 · Cited by 87
The effect of transforming growth factor β on rates of procollagen synthesis and degradation in vitro
McAnulty, R. J., Campa, J. S., Cambrey, A. D., & Laurent, G. J. (1991) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(91)90066-7 · Cited by 82
Inhibin, Activin, and Follistatin Potential Roles in Ovarian Physiologya
Hillier, S. G., & Miró, F. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb43850.x · Cited by 82
Recognition of nascent polypeptides for targeting and folding
Landry, S. J., & Gerasch, L. M. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90060-9 · Cited by 78
Role Of The zerknüllt Gene In Dorsal-Ventral Pattern Formation In Drosophila
Rushlow, C., & Levine, M. (1990) · Advances in Genetics · doi:10.1016/s0065-2660(08)60028-0 · Cited by 68
short gastrulation, a mutation causing delays in stage-specific cell shape changes during gastrulation in Drosophila melanogaster
Zusman, S. B., Sweeton, D., & Wieschaus, E. F. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90389-2 · Cited by 66
The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development
Schonbaum, C. P., Organ, E. L., Qu, S., & Cavener, D. R. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90183-h · Cited by 38
A fast, sensitive pattern-matching approach for protein sequences
Rohde, K. E., & Peer Bork, B. (1993) · Computer applications in the biosciences · doi:10.1093/bioinformatics/9.2.183 · Cited by 28
Intercellular signalling in mesoderm formation during amphibian development
Smith, J. C., Cunliffe, V. T., Green, J. B. A., & New, H. V. (1993) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1993.0070 · Cited by 10
What the papers say: Mesodermal growth factor candidates elected!
Green, J. B. A. (1993) · BioEssays · doi:10.1002/bies.950150209 · Cited by 3

Flagged first, then by citations

Research works printed but not linked: 1

Chasan, R. and K. Anderson. 1993. Maternal control of dorsalventral polarity and pattern in the embryo. In The Development of Drosophila melanogaster (ed. M. Bate and A. Martinez-Arias), vol. 1, pp. 387–424. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

Sorted by citations

TGF-β SIGNAL TRANSDUCTION
Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571
Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4
Piccolo, S., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Cell · doi:10.1016/s0092-8674(00)80132-4 · Cited by 1,127
Direct and Long-Range Action of a DPP Morphogen Gradient
Anthamatten, D., Burke, R., Struhl, G., & Basler, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81114-9 · Cited by 893
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus
Sasai, Y., Lu, B., Steinbeißer, H., & Robertis, E. M. D. (1995) · Nature · doi:10.1038/376333a0 · Cited by 713
Bone morphogenetic proteins in development
Hogan, B. L. M. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80064-5 · Cited by 715

See all 308

Authors: Francois, V, Solloway, M., O'Neill, J. W., Emery, J., & Bier, E.
Affiliations: University of California San Diego (US)
ORCID: Solloway, M
Bier, E
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1994-11-01
Volume: 8
Issue: 21
Pages: 2602-2616
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.8.21.2602
OpenAlex: W2172086325
Cited by: 308
References: 76
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 13 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 5
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: Alfred P. Sloan Foundation
March of Dimes Foundation
McKnight Foundation
Centre National de la Recherche Scientifique
National Institutes of Health (RO1-NS29870, NS29870)
National Institute of Neurological Disorders and Stroke (R01-NS29870-01, R01NS029870)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: short gastrulation, SOG, dorsoventral patterning, Drosophila embryo, DPP, TGF-beta, amnioserosa, dorsal ectoderm, proteolytic cleavage, gene cloning
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Drosophila, Embryo, Nonmammalian, Female, Gastrula, Gene Expression Regulation, Genes, Lethal, Heterozygote, Insect Hormones, Male, Molecular Sequence Data, Gene Expression, Polymerase Chain Reaction, Transforming Growth Factor beta, Genes, Insect, Sequence Homology, Amino Acid, Drosophila Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks