rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.
Open accessAbstract
rhomboid (rho) belongs to a group of four genes involved in the elaboration of positional information at a ventrolateral level in the Drosophila embryo. Mutations at any of these four loci also lead to a variety of other phenotypes, including reduction in the number of stretch receptor organs (chordotonal organs) in the peripheral nervous system (PNS). We have cloned rho with the aid of a lacZ-bearing P-element inserted into the rho gene. In the early blastoderm stage, a putative rho transcript is expressed in ventrolateral strips corresponding to the domain of activity of the rho gene on the embryonic fate map. Later expression of the transcript correlates with regions of the embryo that are disrupted in rho mutants and includes a cell that may be the precursor for the missing stretch receptor organs. We hypothesize that rho acts very early in differentiation pathways to specify the identities of domains and isolated precursor cells. Sequence analysis suggests that this transcript codes for a trans-membrane protein.
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Intermediate levels of nuclear Dorsal present in ventrolateral regions induce expression of genes such as rhomboid and ventral neuroblasts defective, which are important for specification of the neurogenic ectoderm.
“Intermediate levels of nuclear Dorsal, present in ventrolateral regions, induce the expression of genes such as rhomboid (rho) and ventral neuroblasts defective (vnd), which are important for specification of the neurogenic ectoderm”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Bier et al. 1990
The Expression patterns of rho section (page unavailable) reports rho expression in ventrolateral domains, and the introductory section (page unavailable) links ventrolateral genes, including rho, to neural development. The copy does not establish that intermediate levels of nuclear Dorsal induce this expression, and it does not identify ventral neuroblasts defective (vnd) as another induced gene. (LLM, conf=0.86)
Experimental — accuracy not yet measuredClassical genetic screens identified 10 genes that function in the early embryo to control dorsoventral patterning: sna, twi, single-minded, m8, brinker, rho, sog, tld, zen, and dpp.
“Classical genetic screens identified 10 genes that function in the early embryo to control DV patterning (sna, twi, single-minded [sim], m8, brinker [brk], rho, sog, tld, zen, and dpp)”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Bier et al. 1990
The paper’s discussion of dorsoventral patterning in the early embryo identifies twi, sim, zen, dpp, and rho as relevant genes. It does not state that classical screens identified the specified set of 10 genes, and the passages do not support the remaining names in that list. (LLM, conf=0.88)
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- Authors
- Bier, E., Jan, L. Y., & Jan, Y. N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1990-02
- Volume
- 4
- Issue
- 2
- Pages
- 190-203
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2036207377
- Cited by
- 393
- References
- 0
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- peripheral nervous system development, chordotonal organ, transmembrane proteins, Drosophila melanogaster
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, DNA, Drosophila melanogaster, Lac Operon, Molecular Sequence Data, Muscles, Mutation, Peripheral Nerves, Phenotype, Gene Expression
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